Molecular analysis of signaling mechanism of immune cell surface receptors

2014 Fiscal Year Final Research Report

• Project Area: Structural basis of cell-signalling complexes mediating signal perception, transduction and responses
• Project/Area Number: 22121007
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Hokkaido University
• Principal Investigator: MAENAKA KATSUMI 北海道大学, 薬学研究科(研究院), 教授 (10322752)
• Project Period (FY): 2010-04-01 – 2015-03-31
• Keywords: 蛋白質 / 免疫 / 感染症 / X線結晶構造解析 / 受容体 / 創薬科学

Outline of Final Research Achievements

To understand medically important immune response and infection route, it is essential to structure biologicallyvisualize the mutual recognition mechanism in atomic level of immune cell surface receptor as the defense forefront toward cancer cells and pathogens. In this study, as important signal control complexes in immune diseases and infectious diseases, we focused on HVEM signal control complex of co-signaling molecule CD160 on T cells, the complex of NKR-P1 / CD161 receptor expressed in human Th17 cells with ligand LLT1, measles virus surface protein invasion complexes, glycolipid recognition immunoreceptor Mincle and MCL. Structural features extracted from the three-dimensional structures and physicochemical analyses of these complexes promoted advance field "structural molecular medicine".

Free Research Field

蛋白質科学