Searching for signaling molecules in neuro-vascular interaction

2015 Fiscal Year Final Research Report

• Project Area: Vasculo-neural wiring and their interdependent crosstalk
• Project/Area Number: 22122008
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: The University of Tokyo (2013-2015); Osaka Bioscience Institute (2010-2012)
• Principal Investigator: Emoto Kazuo 東京大学, 理学(系)研究科(研究院), 教授 (80300953)
• Co-Investigator(Kenkyū-buntansha): Koizumi Hiroyuki 東京大学, 大学院理学系研究科, 助教 (10334335) ; Kanai Makoto 大阪バイオサイエンス研究所, 神経細胞生物学部門, 研究員 (50598034) ; Kanamori Rei (Morikawa Rei) 大阪バイオサイエンス研究所, 神経細胞生物学部門, 研究員 (50534575)
• Project Period (FY): 2010-04-01 – 2016-03-31
• Keywords: ショウジョウバエ / 末梢感覚ニューロン / 気管 / 伴走構造 / NCAM

Outline of Final Research Achievements

To identify molecules involved in neuro-vascular interaction, we screened molecules involved in neuro-trachea interaction in Drosophila as a model for neuro-vascular interaction. We conducted an RNAi screen for ~100 candidate molecules and found that FasII/NCAM, an adhesion molecule of IgG superfamily, mediates interaction between trachea and axons of sensory neurons in wing disc, which likely navigates afferent axons to the central nervous system.

Free Research Field

発生生物学、神経科学、細胞生物学