Molecular Basis and Disorders of Control of Appetite and Fat Accumulation

2015 Fiscal Year Final Research Report

• Project Area: Molecular Basis and Disorders of Control of Apetite and Fat Accumulation
• Project/Area Number: 22126012
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Kyoto University
• Principal Investigator: HOSODA KIMINORI 京都大学, 医学(系)研究科(研究院), 教授 (40271598)
• Co-Investigator(Renkei-kenkyūsha): MORI Kiyoshi 京都大学, 医学研究科, 准教授 (60343232) ; TOMITA Tsutomu 京都大学, 医学研究科, 助教 (50402897)
• Project Period (FY): 2010-04-01 – 2016-03-31
• Keywords: GPR40 / 脂質異常症 / インスリン抵抗性 / GPCR / インスリン分泌

Outline of Final Research Achievements

We demonstrated that the increase of triglyceride accumulation and the decrease of GPR40 gene expression in the pancreas of genetically obese rats deficient in leption receptor gene.We created GPR40 KO rat and now investigate the abnormalities in glucose and lipid metabolism.We established leptin gene deficient rats as a new genetically obese animal model.We succeeded in differentiation of human iPS cells into adipocyte for the first time in the world. We also established iPS cell lines from congenital lipodystrophy patients, and established a tool for the elucidation of pathogenesis and pathophysiology.

Free Research Field

内分泌代謝学