Development of Systems Cancer Research by Computation and Simulation

2014 Fiscal Year Final Research Report

• Project Area: Integrative Systems Understanding of Cancer for Advanced Diagnosis, Therapy and Prevention
• Project/Area Number: 22134004
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Complex systems
• Research Institution: The University of Tokyo
• Principal Investigator: MIYANO SATORU 東京大学, 医科学研究所, 教授 (50128104)
• Co-Investigator(Kenkyū-buntansha): IMOTO Seiya 東京大学, 医科学研究所, 准教授 (10345027) ; YAMAGUCHI Rui 東京大学, 医科学研究所, 講師 (90380675) ; SHIRAISHI Yuichi 東京大学, 医科学研究所, 助教 (70516880) ; TAMADA Yoshinori 東京大学, 大学院情報理工学研究科, 助教 (80435495) ; SHIMAMURA Teppei 名古屋大学, 医学系研究科, 特任准教授 (00623943) ; NAGASAKI Masao 東京大学, 医科学研究所, 准教授 (90396862)
• Co-Investigator(Renkei-kenkyūsha): HIGUCHI Tomoyuki 大学共同利用機関法人情報, システム研究機構統計数理研究所, 所長 (70202273) ; KAYANO Mitsunori 帯広畜産大学, 畜産学部, 講師 (20590095) ; GOTOH Noriko 東京大学, 医科学研究所, 特任准教授 (10251448)
• Project Period (FY): 2010-04-01 – 2015-03-31
• Keywords: がん / システム生物学 / ゲノム科学 / バイオインフォマティクス / 統計的モデリング

Outline of Final Research Achievements

We developed a new research area “systems cancer research” by fusing large-scale data analysis and mathematical modelling that made full use of mathematics and supercomputers. Methodologies for system cancer research were installed in each cancer study of the members. Methodologies and utilization of supercomputers innovated integrative studies among “wet” and “dry” laboratories. As a result, our comprehensive understanding of cancer systems advanced drastically. Our collaboration with Seishi Ogawa about myelodysplasia (MDS) showed for the first time in the world that the abnormality of the RNA splicing is the cause of MDS. This discovery that abnormal RNA splicing is a cause of cancer held a special place in the pages of cancer research history. Our collaboration with Takashi Takahashi discovered the prognostic hubs and subnetworks which switch survival/death of lung cancer patients.

Free Research Field

バイオインフォマティクス