2016 Fiscal Year Final Research Report
Development of Controlling System for Organocatalysts Based on the Formation of Hydrogen Bonding Network
| Project Area | Advanced Molecular Transformations by Organocatalysts |
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| Project/Area Number |
23105002
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| Research Category |
Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
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| Allocation Type | Single-year Grants |
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| Review Section |
Science and Engineering
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Project Period (FY) |
2011-04-01 – 2016-03-31
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| Keywords | 有機分子触媒 / 不斉合成 / 物質変換 / 水素結合 / 酸触媒 / 環境調和 / 分子認識 / 反応場 |
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| Outline of Final Research Achievements |
The development of highly selective and efficient organic transformation is highly demanded for organic synthesis. In order to establish such reaction system, we designed novel chiral Brønsted acid catalysts which were introduced two or more acidic functional groups to the same catalyst molecule. The design concept of the new catalyst molecules is the formation of intramolecular hydrogen bond between two or more acidic moiety to enhance the acidity of the catalyst molecule. As the result, we successfully developed bis-phopsphoric acid catalyst of which two phosphoric acid moieties were introduced to the catalyst molecule. In addition, on the basis of the design concept of bis- phopsphoric acid catalyst, we further developed C1 symmetric bis-phosphoric acid catalyst to enhance the acidity of the catalyst molecule.
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| Free Research Field |
有機合成化学
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