2015 Fiscal Year Final Research Report
Development of high-speed closed system for analysis and isolation of rare cell populations within the blood
| Project Area | Hyper Bio Assembler for 3D Celluler Innovation |
|---|
| Project/Area Number |
23106004
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
|
| Allocation Type | Single-year Grants |
|---|
| Review Section |
Science and Engineering
|
|---|
| Research Institution | The University of Tokyo |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
Eto Koji 京都大学, iPS細胞研究所, 教授 (50286986)
Kaneko Shin 京都大学, iPS細胞研究, 准教授 (40361331)
|
|---|
| Project Period (FY) |
2011-04-01 – 2016-03-31
|
| Keywords | 微小細胞 / デバイス / がん / 閉鎖系 / 医工学融合 |
|---|
| Outline of Final Research Achievements |
Aiming to develop high-speed closed system for analysis and isolation of rare cell populations within the blood, in this study, we showed the possibility that could detect rare cell populations in blood by the viscoelastic difference (difference in passing time through the microfluidic channel) of the cell. It will be possible to analyze erythroblasts or circulating cancer cells in peripheral blood at high speed while they are in an extra corporeal circulation. Therefor, prenatal diagnosis or prognostic prediction of cancer will be available more easily and exactly by this system.
We successfully achieved in vitro generation of platelets from human pluripotent stem cell derived MKs by a two dimensional flow culture that recapitulates bone marrow blood flow.
|
| Free Research Field |
免疫学、サイトカイン
|
