Construction of 3D cellular system using high-speed micro manipulation

2015 Fiscal Year Final Research Report

• Project Area: Hyper Bio Assembler for 3D Celluler Innovation
• Project/Area Number: 23106005
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Science and Engineering
• Research Institution: Osaka University
• Principal Investigator: Arai Tatsuo 大阪大学, 基礎工学研究科, 教授 (90301275)
• Co-Investigator(Kenkyū-buntansha): Mae Yasushi 大阪大学, 基礎工学研究科, 准教授 (50304027) ; Kojima Masaru 大阪大学, 基礎工学研究科, 助教 (00533647) ; Tanikawa Tamio 独立行政法人産業技術総合研究所, 知能システム研究部門統合知能研究グループ, 研究グループ長 (30357470) ; Ohara Kenichi 名城大学, 理工学部, 准教授 (50517886) ; Yoshikawa Hiroshi 埼玉大学, 理工学研究科, 准教授 (50551173) ; Matsui Hirofumi 筑波大学, 医学医療系, 講師 (70272200)
• Project Period (FY): 2011-04-01 – 2016-03-31
• Keywords: マイクロマニピュレーション / 高速３次元計測 / ３次元細胞システムパーツ / ３次元細胞システム / in vitro 活性

Outline of Final Research Achievements

In this study, we aim to establish a protocol for construction of 3-dimensional cellular systems activated in vitro, following research topic was promoted. 1) Fabrication of tubular cellular parts by the rolling method. 2) Fabrication of tubular cellular parts using a microfluidic chip. 3) Generation of arbitrary shape 3D cellular parts using a robot arm and variable mold. 4) Development of the high-speed construction technology for 3D cellular systems by manipulator. By promoting above, we established a new construction process of arbitrary shape cellular system parts, for example "tubular part" and "lattice shape structure parts". Furthermore, the world's fastest micro-object manipulation for construction of 3D cellular systems was realized by two fingered micro hand system.

Free Research Field

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