2015 Fiscal Year Final Research Report
Neural Circuits Enabling Model-based Decision-making.
| Project Area | Elucidation of neural computation for prediction and decision making: toward better human understanding and applications |
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| Project/Area Number |
23120006
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| Research Category |
Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
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| Allocation Type | Single-year Grants |
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| Review Section |
Complex systems
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| Research Institution | Tamagawa University |
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Principal Investigator |
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| Project Period (FY) |
2011-04-01 – 2016-03-31
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| Keywords | 前頭前野 / 推移的推論 / 選言的推論 / ウイルスベクター / 大脳基底核 / 意思決定 / DREADD |
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| Outline of Final Research Achievements |
To investigate neuronal mechanisms of transitive inference, we recorded single unit activities from the lateral prefrontal cortex (LPFC) and caudate nucleus (Cd) of macaque monkeys while they performed a reward inference task. We found that prefrontal neurons, not basal ganglia neurons, coded the categorical information, which was shown to have a close relation to the ability of transitive inference.
Also, we applied the DREADDs (the Designer Receptors Exclusively Activated by the Designer Drugs) technique to suppress the information transmission in the bilateral LPFC-Cd pathway in the macaque brain. Results suggest that the decrease in the signal transmission in the pathway led to the increase in the discount factor for the trial outcome.
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| Free Research Field |
生理学
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