Neural basis of intuitive and deliberative decision-making impairments in neuropsychiatric disorders

2015 Fiscal Year Final Research Report

• Project Area: Elucidation of neural computation for prediction and decision making: toward better human understanding and applications
• Project/Area Number: 23120009
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Complex systems
• Research Institution: Kyoto University
• Principal Investigator: Takahashi Hidehiko 京都大学, 医学(系)研究科(研究院), 准教授 (60415429)
• Co-Investigator(Kenkyū-buntansha): MIMURA Masaru 慶応義塾大学, 医学部, 教授 (00190728) ; KATO Motoichiro 慶応義塾大学, 医学部, 教授 (80161123) ; SUHRA Tetsuya 放射線医学総合研究所, 脳機能イメージング研究部, 部長 (90216490)
• Project Period (FY): 2011-04-01 – 2016-03-31
• Keywords: 意思決定 / 精神疾患

Outline of Final Research Achievements

We investigated the relationship between noradrenaline transporter (NET) in the brain measured by PET and the degree of loss aversion assessed with an economic experiment in healthy control. We found that individuals with high density of thalamic NET tend to show reckless decision-making (low loss aversion). However, when it comes to gambling disorder patients, there were two subtypes in terms of loss aversion (low and high loss aversion groups). High loss aversion group showed cautious decision-making, which was counterintuitive. High loss aversion group showed differential brain volume reduction in the orbitofrontal cortex. The findings suggest that treatment for gamble disorders should be provided depending on the subtype.

Free Research Field

精神医学