2017 Fiscal Year Final Research Report
Altered function and structure of immune system in ageing and diseases
| Project Area | Analysis and synthesis of multi-dimensional immune organ network |
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| Project/Area Number |
24111008
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| Research Category |
Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Project Period (FY) |
2012-06-28 – 2017-03-31
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| Keywords | T細胞 / 細胞老化 / 免疫老化 / 恒常性増殖 / 老化関連疾患 / 自己免疫病 / 慢性炎症 |
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| Outline of Final Research Achievements |
We have identified a CD4+ T-cell population that exhibits cellular senescence features and increases with age (SA-T cells). The SA-T cells expressed senescence-related genes with SA-secretory phenotype (SASP) and showed a potent inflammatogenic activity with self-reactivity. The SA-T cells are generated after extensive cell divisions in homeostatic proliferation with age. Besides ageing, the SA-T cells are also increased robustly at the lupus-prone background and various tissue stresses and initiate autoimmunity and tissue inflammation such as high fat diet-induced adiposity and insulin-resistance. Current results have revealed that the SA-T cells underlie the systemic autoimmunity and age-related chronic inflammatory disorders.
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| Free Research Field |
免疫学
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