Generation and function of linear ubiquitin chains

2016 Fiscal Year Final Research Report

• Project Area: New aspect of the ubiquitin system : its enormous roles in protein regulation
• Project/Area Number: 24112002
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Kyoto University
• Principal Investigator: IWAI Kazuhiro 京都大学, 医学研究科, 教授 (60252459)
• Project Period (FY): 2012-06-28 – 2017-03-31
• Keywords: 直鎖状ユビキチン鎖 / ユビキチン / NF-kappaB / Bリンパ球 / B細胞リンパ腫 / アスペルギルス

Outline of Final Research Achievements

The ubiquitin conjugation system is one of the most important reversible post-translational modification system that regulates functions of proteins in a wide variety of ways. This is one of the eight research projects of New aspect of the ubiquitin system : its enormous roles in protein regulation an research area of Grant-in-Aid for Scientific Research on Innovative Areas. Pathophysiological roles of the ligase that generate M1-linked chain and mechanism underlying M1-chain generation was studied. Then, I found that 1. M1-chains are essential for the function of B lymphocytes, 2.the ligase (LUBAC) and de ubiquitinating enzymes (OTULIN and CYLD) that are specific for M1-linked chains always form complex and tune strength of NF-kappaB activation elicited by M1-chains, M1-chains are involved in the oncogenesis of B cell lymphomas, and Aspergillus, an opportunistic pathogen for pneumonia, infects to lung by suppressing the generation of M1-chains.

Free Research Field

生体分子医学