2016 Fiscal Year Final Research Report

Role of the ubiquitin system in the regulation of gene expression

Planned Research

Project Area	New aspect of the ubiquitin system : its enormous roles in protein regulation
Project/Area Number	24112004
Research Category	Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
Allocation Type	Single-year Grants
Review Section	Biological Sciences
Research Institution	Tokyo Metropolitan Institute of Medical Science (2016) National Institute of Health Sciences (2012-2015)
Principal Investigator	OHTAKE Fumiaki 公益財団法人東京都医学総合研究所, 生体分子先端研究分野, 主席研究員 (60447373)
Project Period (FY)	2012-06-28 – 2017-03-31
Keywords	ユビキチン / 翻訳後修飾
Outline of Final Research Achievements	Ubiquitination is an essential post-translational modification (PTM) with diverse functions. In this study, we showed that ubiquitin, itself a PTM, is functionally regulated by acetylation. We identified histone H2B as a substrate of acetyl-ubiquitylation. Moreover, we established a strategy for quantifying K48/K63 branched ubiquitin chains, and found a cellular role of the branched ubiquitin chains.
Free Research Field	生物学