2016 Fiscal Year Final Research Report
Host cell competnecy for negative-stranded RNA viruses
| Project Area | Molecular basis of host cell competency in virus infection |
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| Project/Area Number |
24115002
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| Research Category |
Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | University of Tsukuba |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
朴 三用 横浜市立大学, 生命医科学研究科, 教授 (20291932)
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| Research Collaborator |
Kawaguchi Atsushi 筑波大学, 医学医療系, 助教 (90532060)
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| Project Period (FY) |
2012-06-28 – 2017-03-31
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| Keywords | インフルエンザウイルス / RNAポリメラーゼ / RNP / エンドソーム / 微小管 / 小胞輸送 |
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| Outline of Final Research Achievements |
This research aimed to identify host factors, which regulate influenza virus genome function, and to analyze the replicational and post-replicational regulation of influenza virus genome.
We identified pp32/APRIL and Prp18 as stimulatory factors of viral RNA polymerase. Further, we found that newly synthesized viral genomes are recruited to the centrosome by YB-1, and the progeny viral genome is transported to the plasma membrane via cholesterol-enriched Rab11a-positive recycling endosomes. Cholesterol is thought to be a trigger for the virus assembly concomitantly with arrival of the virus genome beneath the plasma membrane.
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| Free Research Field |
ウイルス学
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