Understanding the virus-host network by post genome analysis

2016 Fiscal Year Final Research Report

• Project Area: Molecular basis of host cell competency in virus infection
• Project/Area Number: 24115007
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: National Institute of Advanced Industrial Science and Technology
• Principal Investigator: Natsume Tohru 国立研究開発法人産業技術総合研究所, 創薬分子プロファイリング研究センター, 研究センター長 (00357683)
• Co-Investigator(Kenkyū-buntansha): 伊庭 英夫 東京大学, 医科学研究所, 教授 (60111449)
• Co-Investigator(Renkei-kenkyūsha): INADA Ken_ichi 藤田保健衛生大学, 医学部, 教授 (70246081) ; HIROKAWA Takatsugu 産業技術総合研究所, 創薬分子プロファイリング研究センター, 研究チーム長 (20357867)
• Project Period (FY): 2012-06-28 – 2017-03-31
• Keywords: 宿主細胞コンピテンシー / インフルエンザウイルス / HSV-1ウイルス / 質量分析 / miRNA / TNF-α

Outline of Final Research Achievements

Virus infection is based on a balance between virus-host battle. To prevent virus infection, it is very important to understand its molecular mechanism. As an example of a virus-host battle, we analyzed the influenza virus mediated inhibitory mechanism of TNF-α-mediated immune response and the mechanism of miRNA (miR-199a-3p / -5p) mdeiated inhibition of HSV-1 virus replication. We succeeded in elucidating the molecular mechanism of each battles and clarifying a part of the survival strategy of virus and host. In addition, we have succeeded in identifying novel HSV-1 viral proteins related to neurotoxicity exhibited by HSV-1 virus by proteomic analysis.

Free Research Field

プロテオミクス、ロボティクス、分生生物学、創薬科学