Planned Research
Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
We have determined the crystal structures of the autophagy-initiating Atg1 complex and Atg101, the worm homologs of Atg8 that mediate autophagosome formation and cargo recognition, as well as the selective cargo Ape1 and its adaptor Atg19. By functional analyses based on the structural information, we have revealed the molecular mechanisms of autophagy initiation upon starvation, different functions mediated by Atg8 homologs, and selective recognition of protein aggregates during selective autophagy.
構造生物学
