Investigating the mechanisms for GSC regulation in mouse gametogenesis

2017 Fiscal Year Final Research Report

• Project Area: Mechanisms regulating gamete formation in animals
• Project/Area Number: 25114004
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: National Institute for Basic Biology
• Principal Investigator: YOSHIDA Shosei 基礎生物学研究所, 生殖細胞研究部門, 教授 (60294138)
• Co-Investigator(Kenkyū-buntansha): 原 健士朗 東北大学, 農学研究科, 准教授 (60551546) ; 大保 和之 横浜市立大学, 医学研究科, 教授 (70250751)
• Co-Investigator(Renkei-kenkyūsha): KITADATE Yu 基礎生物学研究所, 生殖細胞研究部門, 助教 (10455214) ; NAKAGAWA Toshinori 基礎生物学研究所, 生殖細胞研究部門, 助教 (50456894) ; HARA Kenshiro 東北大学, 農学研究科, 准教授 (60551546)
• Research Collaborator: Simon Benjamin D. ケンブリッジ大学 ; Jorg David ケンブリッジ大学 ; 小川 毅彦 横浜市立大学 ; 古関 明彦 理化学研究所 ; 小林 悟 筑波大学 ; 高橋 智 筑波大学 ; 中村 隼明 広島大学 ; 高田 慎治 NIBB ; 上野 直人 NIBB
• Project Period (FY): 2013-06-28 – 2018-03-31
• Keywords: 遺伝子 / 幹細胞 / 分化 / クロマチン修飾

Outline of Final Research Achievements

Continual production of numerous sperm in the testes ensured the continuity of life. Here, spermatogenic stem cells play essential roles through giving rise to both the sperm-producing differentiating cells and the self-renewing stem cells, in a well balance manner. This study has contributed toward the understanding of the nature of spermatogenic stem cells by proposing a novel model for the stem cell dynamics, discovering a crucial change in the status of genome DNA, discovery of novel molecular mechanisms making the selfrenewal and differentiation compatible in uniform tissue environment, as well as investigating the mechanisms underlying the stem cell number regulation and post-transplantation repopulation.

Free Research Field

発生生物学