2017 Fiscal Year Final Research Report
Elucidation of structure and function of heterochromatin
| Project Area | Dynamic chromatin structure and function |
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| Project/Area Number |
25116004
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| Research Category |
Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | Osaka University (2016-2017)
Hokkaido University (2013-2015) |
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Principal Investigator |
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| Research Collaborator |
ISOBE Shinya
NAGAO Koji
SADO Takashi
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| Project Period (FY) |
2013-06-28 – 2018-03-31
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| Keywords | ヘテロクロマチン / エピジェネティクス / HP1 / ポリコーム複合体 |
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| Outline of Final Research Achievements |
Heterochromatin is repressive and compacted form of chromatin in the interphase nucleus. This study showed several sides of structure and function of heterochromatin through analysis of HP1 and its binding proteins, as follows. 1) Various complex formation of Histone methyltransferases for repressive chromatin and the molecular basis of their formation, 2) Relationship between heterochromatin formation and repressive histone modification on inactive X chromosome, 3) Involvement of an HP1 binding protein in pathway choice for repairing double-strand breaks.
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| Free Research Field |
分子細胞生物学
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