2017 Fiscal Year Final Research Report
Elucidation of operation principle of glial assembly
| Project Area | Glial assembly: a new regulatory machinery of brain function and disorders |
|---|
| Project/Area Number |
25117003
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
|
| Allocation Type | Single-year Grants |
|---|
| Review Section |
Biological Sciences
|
|---|
| Research Institution | University of Yamanashi |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
伊藤 啓 東京大学, 分子細胞生物学研究所, 准教授 (00311192)
粟崎 健 杏林大学, 医学部, 教授 (60359669)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
SHIGETOMI Eiji 山梨大学, 大学院総合研究部, 助教 (00631061)
|
|---|
| Project Period (FY) |
2013-06-28 – 2018-03-31
|
| Keywords | アストロサイト / 脳卒中 / 神経障害性疼痛 / リモデリング / ショウジョウバエ |
|---|
| Outline of Final Research Achievements |
To elucidate operation principle of glial assembly, we have focused on astrocytes and their assembly, their mode and mechanisms of operation were analyzed. We also used a high-throughput assay system of Drosophila. Using stroke model, we have found that astrocytes as an assembly, respond to very slight ischemic stimuli so-called preconditioning, and changed their phenotypes to neuroprotective ones, leading to induction of ischemic tolerance. Furthermore, in the neuropathic pain model, astrocytes in the primary sensory cortex become synaptogenic phenotypes, and then cross the innocuous network with nocuous neuronal networks, leading to induction of mechanical allodynia. As for a high through-put assay, we identified various genes that are essential for function or development of glial assembly.
Taken together, we have found various modes and mechanisms of astrocytic assembly, which greatly affect brain functions both in physiology and pathophysiology of brain functions.
|
| Free Research Field |
神経化学、神経薬理学、グリア科学
|
