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1990 Fiscal Year Final Research Report Summary

An Integrated Experimental, Preventive and Epidemiological Study on Stress in Modern Society

Research Project

Project/Area Number 01304034
Research Category

Grant-in-Aid for Co-operative Research (A)

Allocation TypeSingle-year Grants
Research Field Hygiene
Research InstitutionHokkaido University

Principal Investigator

SAITO Kazuo  Hokkaido University School of Medicine, Professor., 医学部, 教授 (80000917)

Co-Investigator(Kenkyū-buntansha) ITOKAWA Yoshinori  Faculty of Medicine, Kyoto University, Professor., 医学部, 教授 (80025593)
MORIMOTO Kanehisa  School of Medicine, Osaka University, Professor, 医学部, 教授 (20143414)
TANAKA Heizo  Tokyo Medical and Dental University, Medical Research Institute, Professor., 難治疾患研究所, 教授 (70047215)
AOYAMA Hideyasu  Okayama University Medical School, Professor., 医学部, 教授 (40032875)
SUZUKI Tsuguyoshi  Faculty of Medicine, University of Tokyo, Professor., 医学部, 教授 (80009894)
Project Period (FY) 1989 – 1990
KeywordsStress / Preventive Medicine / Epidemiological Survey / Experimental Medicine / Metabolism / Lifestyle / Trace Elements / DNA
Research Abstract

The investigators had intended to unify the concept and definition of stress at the initial meeting in Aug. 1989, and discussed themes, plans and methods of research at the 2nd. and 3rd. meeting in Nov. 1989 and Fed. 1990 respectively, and then presented the results with new aspects at the final meeting in Feb. 1991. During these 2 years the investigators proceeded with the research programs individually. The presented reports were summarized as follows :
As preventive studies based on field surveys for workers, relationships between subjective recognition of stress and stress factors (H. Aoyama), satisfaction of working-life, lifestyle and primary symptoms (K. Morimoto), health practices and behaviors in free time (T. Suzuki) were clarified. Effect of road traffic noise on sleep was evaluated on EEG quantitatively (S. Suzuki) as a study of stress in usual life.
The roles of stress in onset and progress of cardiovascular disease (H. Tanaka), of peptic ulcer (K. Kawai), and in geriatric hospitalizeds patient (N. Yamashita) were investigated epidemiologically.
The experimental researches included that effects of repeated phase shifts in light. and dark on lipid metabolism (S. Sasagawa), relationships between stress and magnesium deficiency (Y. Itokawa), and cytochrome P-450 (T. Takano), and active oxygen formation, DNA damage by induced catecholamines (S. Kawanishi), and involvement of endogenous monoamine oxidase inhibitors, benzodiazepine receptor ligands (O. Wada), stress-induced protein and hemeoxygenase (R. Tokunaga), the changes and roles of trace elements in body under stress (K. Saito), effects of metallothionein on stressed tissues (K. Nishino), quantitative monitoring by stress-induced metallothionein (Y. Kojima) were clarified.
From these results, it was suggested that systematic research was effective to advance the clarification of stress in modern society.

  • Research Products

    (34 results)

All Other

All Publications (34 results)

  • [Publications] K.Saito: "Effets of Noise on Higher Nervous Aetivity" J.or Sound and Vibration. 127. 419-424 (1988)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] T.Saito.etal.: "Changes in trace elemeut couteuts in not brain regious and in those synaptosowal fractius by immobilizationーstress." Euviron.Res.(1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 中尾寛子 他: "勤労者の「ストレス」の認識に関する調査" 日本衛生学雑誌. 45. 338- (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] S.Suzuki.etal.: "Sleep inducing effets of steady noise" J.ot Sound and Vibration. 130. (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 柳元和 他: "タイプA行動パタ-ンと循環器リスクファクタ-との関連について" 日本衛生学雑誌. 45. 197- (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Y.Ichikawa.etal.: "Biolgical mouitoring for workers exposed to u,4‘ーMeteylenebis (2ーchlovoanilive)" Aw.Iud.Hyg.Assoc.J.51. 5-7 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] S.Inoue.etal: "DNA damge induced by metabolites ofーoーpheuylphevol in the presence of copper(2)iou" Chewical Research in Toxicology. 3. 144-149 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Y.Kanai.etal: "Autagohisw of gammaーamino butyriracidーA receptorーwediaped respouses by aminoーgammaーcarbolines" J.Phavwacol.Exp.Thev. 252. 1269-1276 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] T.Takauo: "Metabolisw of dichlovowethame and the subsequent binding of its product,cavbon wonoxide,to qcochvowe pー450 in pertused not liver" Toxicolgy Letters. 40. 93-96 (1988)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 東あかね.他: "消化性潰傷瘍におけるストレスの評価" Therapaic Research. 12. (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] K.Koshimura.et al: "Effects of choline adwiuistration on in vivo releage and biosynthesis of acetylcholiue in the rat striatum as studied by in vivo brain microdialysis." J.Neunochew. 54. 71-77 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 加納薫.他: "ラット脳内銀結合タンパク質" 日本衛生学雑誌. 45. 509 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] H.Ogawa: "Diurnal variatius of serum lipids and postーhepariu plaswa lipolytic aetivities in SHRSPーーEffects of repeated phase shitts in lightーdark cycles" Japanese Heart Jarnal. 32. (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] S.Taketani: "Induction in Mouse Peritoueal Maerophages of 34 KDa Stress Protein and Hume Oxygeuase by SulfhydrylーReactiue Agluts" J.Biochew. 108. 28-32 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] T.Niioka.etal: "Studies an isduetion of Ziue wetallothiouein by seusory and psyclological stresses in not hiver" J.Trace Eleweuts in Exp Med. 2. 178-179 (1989)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] K.Saito.etol: "Trace Eleweuts and Neurotrawsuitters in the Brain Wader Stress" Hokkaido University Press, 1-130 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 丸山総一郎 他: "ライフスタイルとO0L,O0L研究会編 Quality of LifeーO0Lの目指すものー" リブロ社, 58(129-186) (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] K. Saito.: "Effect of Noise on Higher Nervous Activity." J. Sound and Vibration. 127. 419-424 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] T. Saito, et al.: "Changes in trace element contents in the rat brain regions and in those synaptosomal fractions by immobilization-stress." Environ. Res. (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] H. Nakao, et al: "A study on the recognition of "stress" in workers." Jpn. J. Hyg. 45. 338 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] S. Suzuki., et al.: "Sleep inducing effects of steady noise." J. Sound and Vibration. 130. (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] M. Yanagi, et al.: "Relationship between type a behavior pattern and risk factors of cardiovascular disease." Jpn. J. hyg. 45. 197 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Y. Ichikawa, et al.: "Biological monitoring for workers eXposed to 4, 4'-Methylenebis (2-chroloaniline)." Am. Ind. Hyg. Assoc. J. 51. 5-7 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] S. Inoue, et al.: "DNA damage induced by metabolites of o-phenylphenol in the presence of copper(II) ion." Chem. Res. in Toxic. 3. 144-149 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Y. Kanai, et al.: "Antagonism of gamma-aminobutyric acid-A receptor-mediated responces by amino-gamma-carbolines." J. Pharmacol. Exp. Ther. 252. 1269-1276 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] T. Takano.: "Metabolism of dichloromethane and the subsequent binding of its product, carbon monoxide, to cytochrome P-450 in pertused rat liver." Toxic. Letters. 40. 93-96 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] A. Higashi.: "A comparative study of psychosocial factors in peptic ulcer disease." Therapeutic Research. 12. (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] K. Koshimura, et al.: "Effects of choline administration on in vivo release and biosynthesis of acetylcholine in the rat striatum as studied by in vivo brain microdyalysis." J. Neurochem. 54. 71-77 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] K. Kano, et al.: "Silver-binding protein in the rat brain." Jpn. J. Hyg. 45. 509 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] H. Ogawa.: "Diurnal variations of serum lipids and post-heparin plasma lipolytic activities in SHRSP -- Effects of repeated phase shifts in light-dark cycles." Jpn. Heart J. 32. (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] S. Taketani.: "Induction in mouse peritoneal macrophages of 34 KDa stress・protein and heme oxygenase by sulfhydryl-reactive agents." J. Biochem. 108. 28-32 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] T. Niioka, et al.: "Studies on induction of zinc matallothionein by sensory and psychological stresses in rat liver." J. Trace Elements in Exp. Med. 2. 178-179 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] K. Saito, et al.: Hokkaido University Press. Trace Elements and Neurotransmitters in the Brain under Stress., 1-130 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] S. Maruyama, et al.: Libro. Quality of Life. in ed. Lifestyle and QOL., 129-186 (1990)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1993-08-12  

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