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1991 Fiscal Year Final Research Report Summary

Co-operative Research on the Clinical Application of Liver Transplantation.

Research Project

Project/Area Number 01304041
Research Category

Grant-in-Aid for Co-operative Research (A)

Allocation TypeSingle-year Grants
Research Field General surgery
Research InstitutionOsaka University

Principal Investigator

MORI Takesada  Osaka University, Medicine, Professor, 医学部, 教授 (60028496)

Co-Investigator(Kenkyū-buntansha) TANIGAWA Kyuichi  Kurume University, Medicine, Professor, 医学部, 教授 (10080649)
DOHI Yukihiko  Hirosima University, Medicine, Professor, 医学部, 教授 (90034024)
TAKAGI Hiroshi  Nagoya University, Medicine, Professor, 医学部, 教授 (70154755)
OZAWA Kazue  Kyoto University, Medicine, Professor, 医学部, 教授 (00026858)
UCHIDA Hisanori  Tokyo University, Medical Science, Professor, 医科学研究所, 教授 (30050420)
Project Period (FY) 1989 – 1991
KeywordsLiver transplantation / end-stage liver disease / indication / national network / registration system / perioperative management / rejection / organ preservation
Research Abstract

In the western countries, liver transplantation has been accepted as a state-of-the-art therapy for end-stage liver diseases. In contrast, no liver transplantations from brain-dead donors have been performed yet in our country. The aim of this multi-center study is to investigate various medical problems related with liver transplantation and to establish a computed registration system of recipients, in order to start successful liver transplantation program in Japan.
The problems investigated include: 1) indications of liver transplantation, based on the characteristics of the liver diseases in our country, 2) fundamental research on immunosuppression, 3) research on the pre-, intra-, and post-operative management of liver recipients, 4) fundamental research on liver preservation and refinement of operative techniques of the donor operation, and 5) development of a national registration system using a computer, as a part of national network system for liver transplantation.

  • Research Products

    (12 results)

All Other

All Publications (12 results)

  • [Publications] Kawai M: "Differential involvement of CD4^+ cells in mediating skin graft rejection against different amounts of transgenic H-2Kb antigen." J Exp Med. 173(1). 261-264 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ohzato H: "Improvement in islet yield from a cold-presepved pancreas by pancreatic ductal collagenase distention at the time of harvesting." Transplantation. 51(3). 566-570 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Seiji Marubayashi: "Role of conversion of xanthine dehydrogenase to oxidase in ischemic rat liver cell injury" SURGERY. 110(3). 537-543 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] N.Ohkohchi,M: "Role of Free Radicals and Energy Synthesis on Primary Graft Nonfunction in Liver Transplantation" Transplantation Proceeding. 23(5). 2416-2419 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 織井 崇: "温阻血・再潅流に伴う肝細胞膜の機能傷害に関する検討( ^<31>P-MRSおよび ^<23>Na-MRSを用いて)" 肝臓. 31(12). (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 柿添 三郎: "地域国立基幹病院における肝疾患患者の予後ー肝臓移植の適応を考慮してー" 日本消化器病学会雑誌. 88(9). (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Monden M: "Proceeding of the First Congress of Asian Society of Transplantation." Asian Transplantation Society, (1989)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 王 国新: "Cytoprotection and Biology Vol.8" 蟹書房, (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kawai M: "Differential involvement of CD4^+ cells in mediating skin graft rejection against different amounts of transgenic H-2Kb antigen." J Exp Med. 173(1). 261-264 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ohzato H: "Improvement in islet yield from a cold-presepved pancreas by pancreatic ductal collagenase distention at the time of harvesting." Transplantation. 51(3). 566-570 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Seiji Marubayashi: "Role of conversion of xanthine dehydrogenase to oxidase in ischemic rat liver cell injury" SURGERY. 110(3). 537-543 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] N. Ohkohchi, M: "Role of Free Radicals and Energy Synthesis on Primary Graft Nonfunction in Liver Transplantation" Transplantation Proceedings. 23(5). 2416-2419 (1991)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1994-03-18  

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