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1991 Fiscal Year Final Research Report Summary

Research on the relationship between environments and heredity

Research Project

Project/Area Number 01480202
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field 公衆衛生学
Research InstitutionDept. of Maternal and Child Health, Univ. of Tokyo

Principal Investigator

HIGURASHI Makoto  Univ. of Tokyo, Dept. of MCH, Professor, 医学部(医), 教授 (00010223)

Co-Investigator(Kenkyū-buntansha) IIJIMA Sumio  Yamanashi Med. School, Dept. of Health Sciences, Associate Professor, 医学部, 助教授 (70114361)
TAKADAYA Kumiko  Univ. of Tokyo, Dept. of MCH, Instructor, 医学部, 教務職員 (20125983)
ODA Masaaki  Univ. of Tokyo, Dept. of MCH, Instructor, 医学部, 助手 (20160872)
Project Period (FY) 1989 – 1991
KeywordsDown syndrome / Klinefelter syndrome / Recklinghausen disease / SCE / Mutagen
Research Abstract

Down syndrome, Klinefelter syndrome, and Recklinghausen disease are hereditary disorders characterized by congenital malformations, and a high risk of malignancy. Cultured lymphocytes from the patients with these disorders showed more chromosomal sensitivity after irradiation or to mitomycin-C than do normal control subjects.
The chromosomal sensitivity to mitomycin-C (MMC) and cell-cycle kinetics in cells from patients with Klinefelter syndrome, and Recklinghausen disease were studied by techniques of sisterchromatid exchanges (SCEs). In Klinefelter syndrome the frequencies of MMC-induced SCEs increased in proportion to the increase in MMC, concentration in both patient and normal control cells. At low levels of MMC there were no significant differences in SCE frequencies between the patient and normal control cells, but at MMC concentrations of 3X10^<-8>M (p<0.05) and 1X10^<-7> M (p<0.01), significant increases in the frequency of MMC-induced SCEs were observed in cells from patients compared to cells from normal controls. Although the analysis of cell-cycle kinetics both after various culture times and after treatment with MMC revealed that there were no significant differences between the patient and normal control cells, patients with Klinefelter syndrome showed a tendency to cell-cycle delays after treatment with MMC in comparison with normal controls. In Recklinghausen disease, the sensitivity to MMC showed the heterogeneity in response.

  • Research Products

    (11 results)

All Other

All Publications (11 results)

  • [Publications] Higurashi,M.et al.: "Livebirth prevalence and follow-up of malformation syndromes in 27,472newborns" Brain and Development. 12. 770-773 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 塩沢 全司,日暮 眞他: "成人ダウン症候群の睡眼時の病態" 自津神経. 27. 260-267 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 日暮 眞: "胎児治療と倫理" 産婦人科治療. 63. 383-388 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Iijima,K.,Higurashi,M.et al.: "SCE frequency in human and simian lymphoid cell lines infected with simian retroviruses closely related to human T-cell leukemia virus type-I" Yamanashi Med.J.6. 31-37 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 織田 正昭: "高層住宅と子ども" 公衆衛生. 55. 312-316 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Fukuoka,H.,Higurashi,M. et al.: "Heterogeneity of serum and amniotic fluid prolactin in humans." Horm.Res.35. 58-63 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 日暮 眞(分担): "臨床遺伝学" 診断と治療社, 300 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Higurashi, M. et al.: "Livebirth prevalence and follow-up of malformation syndromes in 27, 472 newborns" Brain and Development. 12. 770-773 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Iijima, K., Higurashi, M. et al.: "SCE frequency in human and simian lymphoid cell lines infected with simian retroviruses closely related to human T-cell leukemia virus type-I" Yamanashi Med. J.6. 31-37 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Fukuoka, H., Higurashi, M. et al.: "Heterogeneity of serum and amniotic fluid prolactin in humans." Horm. Res.35. 58-63 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Matsuoka, M., Higurashi, M. et al.: "The development of sleep and Wakefulness cycle in early infancy and its relationship to feeding habit." Tohoku J. Exp. Med.165. 147-154 (1991)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1993-03-16  

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