1990 Fiscal Year Final Research Report Summary
Basic and Clinical Analysis of Macroscopic and Microscopic Characteristics of Coronary Circulation in Cardiac Hypertrophy
| Project/Area Number |
01480253
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Kawasaki Medical School |
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Principal Investigator |
KAJIYA Fumihiko Department of Medical Engineering, Kawasaki School, 医学部・医用工学, 教授 (70029114)
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| Co-Investigator(Kenkyū-buntansha) |
TADAOKA Shinichiro Division of Cardiology, Kawasaki Medical School, 医学部・循環器内科, 講師 (30188255)
OGASAWARA Yasuo Department of Medical Engineering, Kawasaki Medical School, 医学部・医用工学, 講師 (10152365)
TSUJIOKA Katsuhiko Department of Medical Engineering, Kawasaki Medical School, 医学部・医用工学, 助教授 (30163801)
TAKAORI Masuhiko Department of Anesthesiology, Kawasaki Medical School, 医学部・麻酔科, 教授 (30068978)
FUJIWARA Takashi Department of Surgery, Kawasaki Medical School, 医学部・心臓外科, 教授 (90090224)
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| Project Period (FY) |
1989 – 1990
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| Keywords | cardiac hypertrophy / coronary artery flow / intramyocardial vessel / ultrasound Doppler catheter / laser Doppler velocimeter / レ-ザドプラ血流計 |
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| Research Abstract |
It is well known that the heart can adapt itself to pressure overload or volume overload by inducing cardiac hypertrophy and thus reducing myocardial stress. Whereas, it is indicated that coronary reserve is decreased in hypertrophied heart. However, only little finding is reported on why coronary circulation is deteriorated in cardiac hypertrophy.
In this study we measured coronary artery flow in human being with cardiac hypertrophy by 20 MHz ultrasound Doppler velocimeter, and epicardial and intramyocadial artery flow in dogs by laser Doppler velocimeter.
We found that myocardiac contraction impedes coronary inflow and it may affect directly to intramyocardial vessels and the effect of intramyocadial pressure is relatively small. In addition we found that in human cardiac hypertrophy there exists reverse arterial flow in systole and that early diastolic flow is reduced. These findings suggest that myocadial contraction is a major factor determining phasic arterial flow and cardiac hypertrophy has complex effects on coronary circulation.
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