1991 Fiscal Year Final Research Report Summary
The study of the brain receptors in schizophrenia and affective disorders.
| Project/Area Number |
01480282
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Psychiatric science
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| Research Institution | Yokohama City University |
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Principal Investigator |
KISHIMOTO Hideji Associate Professor Department of Psychiatry Yokohama City University, 医学部・神経科, 助教授 (60161444)
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| Co-Investigator(Kenkyū-buntansha) |
FUJITA Haruhiro Assistant professor Department of Psychiatry Yokohama City University, 医学部・神経科, 講師 (00229006)
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| Project Period (FY) |
1989 – 1991
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| Keywords | PET / schizophrenia / affective disorders / CBF / CMRO2 / glutamic acid pools / receptors / グルタミン酸プ-ル |
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| Research Abstract |
Using the tracer of C1502, 1502 and 11C-glucose, the authors measured the cerebral blood flow (CBF), the cerebral metabolic rate of oxygen (CMRO2) and glutamic acid pools by PET in acute and chronic schizophrenic patients, manicdepressive patients who have not received antipsychotic drugs and in control subjects. Diagnosis of disorders were done by DSM-III-R criteria.
The CBF and CMRO2 were under 60ml or 6ml/100gr brain/min in normal controls. The CBF and CMRO2 were increased over 80ml or 8ml/100gr brain/min in the thalamus, the cingulate and the temporal cortex in acute schizophrenic patients, who have no drugs. On the other hand the CBF, CMRO2 and glutamic acid pools were decreased in the association areas of the cortex in chronic schizophrenic patients. These decreases or increases in the CBF, the CMRO2 and glutamic acid pools in schizophrenic patients have a tendency to return to normal values after antipsychotic drug therapy.
The bipolar manic patients showed globally increased cortical glutamic acid pools, whereas unipolar depressed patients showed reduced cortical glutamic acid pools.
The most impaired cortical areas in chronic schizophrenic patients were Brodmann's areas 10, 38, 40 which are named the association areas where human being are creative : language, concept, culture and society.
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