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1990 Fiscal Year Final Research Report Summary

Generation and development of gastric carcinoma from the view point of distribution and function of nerve fibers in the gastric wall.

Research Project

Project/Area Number 01480321
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Digestive surgery
Research InstitutionUniversity of Tokyo

Principal Investigator

KAMINISHI Michio  Department of Surgery III,lecturer, 医学部(分), 講師 (30126031)

Co-Investigator(Kenkyū-buntansha) MASAKI Yukiyoshi  Department of Surgery III,resident, 医学部(分), 医員 (50209417)
CHIU Ming Ling  Department of Surgery III,assistant, 医学部(分), 助手 (70186344)
YASUDA Hidemitsu  Department of Surgery III,assistant, 医学部(分), 助手 (00167694)
OOHARA Takeshi  Department of Surgery III,professor, 医学部(分), 教授 (20010217)
Project Period (FY) 1989 – 1990
KeywordsGastric cancer / Intragastric nerve fiber / Gut-brain hormone / Duonenogastric reflux / Atrophic gastritis / PCNA / Gastric stump carcinoma
Research Abstract

1. We investigated the change of distribution of neuropeptides containing nerve fibers in the gastric wall in rat model of chronic gastritis-intestinal metaplasia by instillation of NaOH in the stomach. S-100 positive nerve fibers showed no remarkable change. GRP containing nerve fibers disappeared just after gastric mucosal injury, but gradually recovered with healing of gastric ulcarative lesions. NPY positive nerve fibers showed a mild change in the muscularis propria.
2. The effect of gastric mucosal denervation on carcinogenesis was studied. In a model of gastric carcinoma induced by duodenogastric reflux and administration of carcinogenic agent, the denervated group showed significant increases of gastric carcinoma and adenoma compared to the control group. In a model of gastric stump carcinoma, where no carcinogenic agent was given, denervation of the gastric stump significantly enhanced the development of carcinoma and tumrous lesion. Moreover, the denervated group showed a prog … More ress of atrophic change and a significant increase of labeling index of PCNA in the gastric mucosa.
3. The distribution of neuropeptides containing nerve fibers in the resected specimen from gastric cancer patients was investigated. S-100 positive nerve fibers were observed in the submucosa and muscularis mucosae, and also in the deep layr of the mucosa in cases with showing a minor change of the gastric mucosa. NF positive nerve fibers were constantly observed in the submucosa but not in the mucosa. Each of GRP,VIP and NPY positive nerve fibers was not observed, and this phenomenon is assumed to be closely related to severity of gastric mucosal changes.
4. Accordingly, it has been clarified that the innervation of the gastric mucosa plays an important role in the development of gastric mucosal changes and gastric tumors. Therefore, the relationship among the intragastric concentration of carcinogenic agents, gastric mucosal changes, distribution of neuropeptide containing nerve fibers and activity of cell proliferation factors should be elucidated. Less

  • Research Products

    (12 results)

All Other

All Publications (12 results)

  • [Publications] 上西紀夫,大原 毅,邱 明麟 ほか: "迷走神経切離後の胃癌発生に及ぼす十二指腸液胃内逆流の影響について" 消化器癌の発生と進展. 1. 213-218 (1989)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 上西紀夫,大原 毅,邱 明麟,安田秀光 ほか: "胃癌発生に及ぼす迷切術および十二指腸液胃内逆流のプロモーション作用についての検討" 消化器癌の発生と進展. 2. 21-25 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 上西紀夫,大原 毅,邱 明麟,安田秀光 ほか: "迷切兼胃切除後の残胃癌発生についての実験的検討" 消化器癌の発生と進展. 3. 87-92 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kaminishi M,Oohara T,Chiu ML,et al.: "Severe gastric mucosal changes following vagotomy with duodenogastric reflux." J Cli Gastroenterol. 14(suppl). S15-S24 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 上西紀夫,大原 毅 ほか: "-発癌に関する基礎研究と治療への応用- 胃癌発生に及ぼす胃粘膜脱神経支配の影響についての検討" 日本外科学会誌. 92(印刷中). (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 下山省二,上西紀夫,正木幸善,大原 毅 ほか: "慢性胃炎モデルにおける胃粘膜内神経分布の変化についての検討" Therapeutic Research. 13. (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kaminishi M,Oohara T.Chiu ML,et al.: "Effects of duodenogastric reflux on gastric carcinogenesis following vagotomy" Proc Jpn Res Soc Gastroenterol Carcinogenesis 1. 213-218 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kaminishi M,Oohara T,Chiu ML,Yasuda H,et al.: "Promotive action of vagotomy with duodenogastric reflux on gastric carcinogenesis" Proc Jpn Res Soc Gastroenterol Carcinogenesis 2. 21-25 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kaminishi M,Oohara T,Chiu ML,Yasuda H,et al.: "An experimental study of carcinogenesis following gastrectomy with vagotomy" Proc Jpn Res Soc Gastroenterol Carcinogenesis 3. 87-92 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kaminishi M,Oohara T,Chiu ML,et al.: "Severe gastric mucosal changes following vagotomy with duodenogastric reflux." J Cli Gastroenterol. 14 (suppl). S15-S24 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kaminishi M,Oohara T,et al.: "Effects of gastric denervation on gastric carcinogenesis" Jpn J Surg. 92 (in press). (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Shimoyama S,Kaminishi M,Masaki Y,Oohara T,et al.: "Changes of distribution of intragastric nerve fiber in a model of chronic gastritis in the rat" Therapeutic Research. 13 (in submission). (1992)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1999-03-16  

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