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1990 Fiscal Year Final Research Report Summary

Establishment of Method for Therapeutic Drug Monitoring with Use of Hair

Research Project

Project/Area Number 01480501
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field 応用薬理学・医療系薬学
Research InstitutionHamamatsu University School of Medicine

Principal Investigator

UEMATSU Toshihiko  Hamamatsu Univ. Sch. Med., Ass. Prof., 医学部, 文部教官助教授 (50151832)

Co-Investigator(Kenkyū-buntansha) NAKASHIMA Mitsuyoshi  Hamamatsu Univ. Sch. Med., Prof., 医学部, 文部教官教授 (00092982)
Project Period (FY) 1989 – 1990
KeywordsHair / Patient compliance / Dosage history / Haloperidol / Ofloxacin / Nicotine / HPLC / Smoking history
Research Abstract

Antipsychotic haloperidol, which may be used in psychiatric patients for a long period of time, was shown to be excreted into hair in proportion to the dose. In addition, the excreted drug was retained in haier for a long time and moved along the hair length at a pace of individual hair growth. However, there was no small inter-individual difference in hair growth rate. To overcome this, such a drug that may be used frequently and independently of the original disease, and excreted in hair to a large extent, was screened. Antimicrobial ofloxacin is proved to be the drug and the method to extract it from hair and to quantify it was developed. Using healthy male volunteers ofloxacin was shown to be detected in hair even after the administration of one tablet and to be excreted into hair in proportion to the dose. From patients who had taken on ofloxacin, hair samples were taken every month for three months. Using these hair sample, ofloxacin was also shown to move along hair length keeping the pace with the hair growth. Therefore, it is expected that we can know the individual rate of hair growth from the distribution of ofloxacin along hair length and the past history of ofloxacin uses. As an example of the application of drug analysis to the knowledge of patient compliance, the distribution of nicotine along hair growth was used to know the time course of refrainment from smoking habits in subjects who attended the 6-month course for smoking refrainment. The distribution of nicotine along hair length coincided exactly to the time course of smoking refrainment.

  • Research Products

    (28 results)

All Other

All Publications (28 results)

  • [Publications] Uematsu,T.et al.: "Human scalp hair as eridence of indiridual dosage history of haloperidol:Prospective study." European Jouraal of Clinical Pharmacology. 37. 239-244 (1989)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Sato,R.et al.: "Human scalp hair as eridence of indiridual dosage history of haloperidol : Prospective study" Therapeutic Drug Monitoring. 11. 686-691 (1989)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Uematsu,T.et al.: "Human scalp hair as eridence of individual dosage history of haloperidol:Apossible linkage of haloperidol excretion int hair" Archives of Dermatological Research. 282. 120-125 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Matsuno,H.et al.: "The measurement of haloperidol and reduud haloperidol in Hair as an index of dosage history" British Journal of Clinical pharmacology. 29. 187-194 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 植松 俊彦 他: "我が国における臨床薬理学の現状" 日本薬剤師会雑誌. 42. 499-504 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 植松 俊彦: "毛髪内薬物濃度モニタリング" 日本病院薬剤師会雑誌. 26. 179-180 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Uematsu,T.et al.: "Human scalp hair as evidence of indiridual dosage history of haloperidol:Longerーtetm followーup study" Therapeutic Drng Monitoring. 12. 582-583 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Uematsu,T.et al.: "The measurement of haloperidol and reduced haloperidol in neonatal hair as an index of placental transfer" Therapeutic Drug Monitoring.

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Uematsu,T.et al.: "The measurement of ofloxacin in hair as an index of exposure to the drug and use of it as a timeーmarker" European Journal of Clinical Pharmacology.

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Uematsu,T.et al.: "The effect of melanin on the pharmacokinetics of ofloxacin and its excretion in hair" Jornal of pharmaceutical Sciences.

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 植松 俊彦: "E.薬効評価のための新しい臨床薬理学的手法 中島光好編 「続医薬品の開発第30巻 薬効評価」" 広川書店,

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 植松 俊彦 他: "VI.キノロンの薬理VIー2キノロンの体内動態と組織移行性 三橋進編 「ニュ-キノロン」" 学会出版センタ-,

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 植松 俊彦 他: "8.臨床薬理学からみたキノロン薬 上田泰他編 「キノロン薬」" ライフ・サイエンス,

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Uematsu,T.et al.: "Pharmacokinetic aspects of newer guinolones “Progress in Drug Research"" Birkhauser Verlag,

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Uematsu T. Sato R, Suzuki K et al.: "Human scalp hair as evidence of individual dosage history of haloperidol : Method and retrospective study." Eur J CIIn Pharmacol. 37. 239-244 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Sato R, Uematsu T, Sato R et al.: "Human scalp hair as evidence of individual dosage history of haloperidol : Prospective study." Ther Drug Monit. 11. 686-691 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Uenatsu T, Sato R, Fujimori O et al.: "Human scalp hair as evidence of individual dosage history of haloperidol : A possible linkage of haloperidol excretion into hair with hair pigment." Arch Dermatol Res. 282. 120-125 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Matstno H, Uematsu T, Nakashima M: "The measurement of haloperidol and reduced haloperidol in hair as an index of dosage history." Br J Clin Pharmacol. 29. 187-194 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Uematsu T, Nakashima M: "The present status of clinical pharmacology in Japan." J Jap Ass Pharm. 42. 499-504 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Uematsu T: "Monitoring of drug concentration in hair" J Jap Ass Hosp Pharm. 26. 179-180 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Uematsu T, Sato R: "Human scalp hair as evidence of individual dosage history of haloperidol : Longer-term follow-up study." Ther Drug Monit. 12. 582-583

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Uematsu T, Yamada K, Matsuno H et al.: "The measurement of haloperidol and reduced haloperidol in neonatal hair as an index of placental transfer of maternal haloperidol." Ther Drug Monit.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Uematsu T, Miyazawa N, Nagashima S et al.: "The measurement of ofloxacin in hair as an index to exposure of the drug and use of it as a time-marker of hair growth." Eur J Clin Pharmacol.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Uematsu T, Miyazawa N, Okazaki O et al: "The effects of melanin on the pharmacokinetics of ofloxacin and its excretion in hair." J Pharm Sci.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Uematsu T: "E. Newer methods for clinical drug evaluation" Clinical evaluation of drug effect.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Uematsu T, Naganuma H, Matsubayashi et al: "VI-2 Pharmacokinetics and tissue penetration of newer quinolones" New quinolones.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Uematsu T, Nakashima M: "8. Qunolones from the view point of clinical pharmacology" Quinolones.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Uematsu T, Nakashima M: "Pharmacoklinetic aspects of newer quinolones" Progress in drug research.

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1993-08-12  

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