1990 Fiscal Year Final Research Report Summary
Anti-cardiolipin antibody as a possible marker for evaluating fetal risk in patients with systemic lupus erythematosus
| Project/Area Number |
01570350
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
内科学一般
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| Research Institution | Chiba University |
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Principal Investigator |
TAKABAYASHI Katsuhiko Chiba Univ. School of Med,, 医学部・第二内科, 助手 (90188079)
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| Co-Investigator(Kenkyū-buntansha) |
KOIKE Takao Chiba University School of Medicine, assistant, 医学部第二科, 助手 (80146795)
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| Project Period (FY) |
1989 – 1990
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| Keywords | systemic lupus erythematosus / fetal loss / anti-cardiolipin antibody / glucocorticoid / fetal prognosis / 胎児予後 |
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| Research Abstract |
To identify the correlation between incidence of anti-phospholipid antibodies and fetal prognosis in pregnant SLE patients, we measured the amount of anti-cardiolipin antibody in their sera, using solid-phase enzyme immunoassay (EIA) methods. Findings in the group having poor obstetric results (fetal loss group) and in those with a history of full-term births (live birth group) were compared with regard to other anti-phospholipid antibodies. The incidence of IgG class anti-cardiolipin antibody was 60% in the fetal loss group and 19% in the live birth group, (P<0.05). The incidence of the other anti-phospholipid antibodies, including lupus anticoagulant and biological false positive serological test for syphilis (BFP-STS), did not differ significantly between the two groups. Therefore, the presence of IgG class anti- cardiolipin antibody may prove to be a useful marker for evaluating fetal risk in SLE patients.
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[Publications] Takabayashi,K.,Koike,T.,Kurasawa,K.,Matsumura,R.,Sato,T.,Tomioka,H.,Ito,I.,Yoshiki,T.,Yoshida,S.: "Effect of FKー506,a novel immunosuppressive drug on murine SLE." Clin.Immunol.Immunopathol.51. 110-117 (1989)
Description
「研究成果報告書概要(和文)」より
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[Publications] Shimada,K.,Koike,T.,Ichikawa,K.,Tsutsumi,A.,Takabsyashi,K.,Tomioka,H.,Toshida,S.: "IgG class antiーcardiolipin antibody as a possible marker for evaluating fetal risk in patients with systemic lupis erythematosus" J.Autoimmunity. 2. 843-849 (1989)
Description
「研究成果報告書概要(和文)」より
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[Publications] Shigemoto,K.,Maruyama,N.,Itoh,Y.,Kubo,S.,Koike,T.,: "Murine leukemia virus gene product as an phase protein:Complere suppression of serum gp70 synthesis in hepatocytes of B10.S mice." Clin.Exp.Immunol.78. 484-487 (1989)
Description
「研究成果報告書概要(和文)」より
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[Publications] kurasawa,K.,Koike,T.,Matsumura,R.,Takabayashi,K.,Tomioka,H.,Ito.I.,Yoshida,S.: "The immunosuppressive FKー506 prevents progression of diabetes in in NOD mice." Clin.Immunol.Immunopathol.57. 274-279 (1990)
Description
「研究成果報告書概要(和文)」より
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[Publications] Hiruma,K.,Kioke,T.,Nakamura,H.,Sato,T.,Maeda,T.,Tomioka,H.,Yoshida,S.,Fujita,T.: "Somatostatin receptors on human lymphocytes and leukemic cells" Immunolgy. 71. 480-485 (1990)
Description
「研究成果報告書概要(和文)」より
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[Publications] Ichikawa, K., Shimada, K., Nawata, Y., Ishii, T., Tomioka, H., Yoshida, S., Koike, T.: "Monoclonal hybridoma anti-cardiolipin antibodies from SLE mice" Clin. Exp immunol.74. 110-114 (1988)
Description
「研究成果報告書概要(欧文)」より
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[Publications] Tsutsumi, A., Koike, T., Ichikawa, K., Shimada, K., Takabayashi, K., Tomioka, H., Yoshida, S.,: "IgG subclass distribution of anti-cardiolipin antibody in patients with systemic lupus crythematosus" J. Rheumatol. 15. 1764-1767 (198)
Description
「研究成果報告書概要(欧文)」より
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[Publications] Matsumura, R., Kondo, Y., Sugiyama, T., Sueishi, M., Koike, T., Tomioka, H., Yoshida, S.: "Immunohistochemical identification of infiltrating mononuclear cells in tubulointerstitial nephritis associated with Sjogren's syndrome." Clin. Nephrol. 30. 335-340 (1988)
Description
「研究成果報告書概要(欧文)」より
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[Publications] Takabayashi, K., Koike, T., Kurasawa, K., Matsumura, R., Sato, T., Tomioka, H., Ito, I., Yoshiki, T., Yoshida, S: "Effect of FK-506, a novel immunosuppressive drug on murine SLE." Clin. Immunol. Immunopathol.51. 110-117 (1989)
Description
「研究成果報告書概要(欧文)」より
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[Publications] Shimada, K., Koike, T., Ichikawa, K., Tsutsumi, A., Takabayashi , K., Tomioka, H., Yoshida, S.: "IgG class anti-cardiolipin antibody as a possible marker for evaluating fetal risk in patients with systemic lupus erythematosus." J. Autoimmunity. 2. 843-849, (1989)
Description
「研究成果報告書概要(欧文)」より
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[Publications] Kurasawa, K., Koike, T., Matsumura, R., Takabayashi, K., Tomioka, H., Ito, I., Yoshida, S.: "FK-506 prevents progression of diabetes in NOD mice." Clin. Immunol. Immunopathol. 57. 274-279 (1990)
Description
「研究成果報告書概要(欧文)」より
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[Publications] Hiruma, K., Koike, T., Nakamura, H., Sato, T., Maeda, T., Tomioka, H., Yoshida, S., Fujita, T.: "Somatostatin receptors on human lymphocytes and leukemia cells." Immunology. 71. 480-485 (1990)
Description
「研究成果報告書概要(欧文)」より
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[Publications] Tsutsumi, A., Koike, T., Sugiyama, T., Matsumura, R., Sueishi, M., Takabayashi, K., Tomioka, H., Yoshida, S.: "Protein losing entheropathy in systemic lupus erythematosus, mixed connective tissue disease and Sjogren's syndrome." Ann. Rheum. Dis.
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「研究成果報告書概要(欧文)」より
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[Publications] Sumida, T., Maeda, T., Koike, T., Tomioka, H., Yoshida, S., Takemori, T., Rajewsky, K.: "Expression of IgH promoter/enhancer Ly-1 transgene in hematopoietic chimeric mice generated by embryonic stem (ES) cell line." Int. Arch. Allergy Appl. Immunol.
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「研究成果報告書概要(欧文)」より
