1991 Fiscal Year Final Research Report Summary
MR (Magnetic Resonance) Evaluation of Bone Marrow Dynamics in Hematological Disorders
| Project/Area Number |
01570594
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Radiation science
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| Research Institution | Saitama Medical School |
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Principal Investigator |
HESHIKI Atsuko Saitama Medical School Department of Radiology Professor and Chairman, 医学部, 教授 (60008589)
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| Co-Investigator(Kenkyū-buntansha) |
HIRASHIMA Kunitake Saitama Medical School Department of 1st Internal Medicine Professor and Chairma, 医学部, 教授 (00165169)
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| Project Period (FY) |
1989 – 1991
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| Keywords | Bone Marrow MRI / STIR / Myelodysplastic Syndrome / Multiple Myeloma / Aplastic Anemia / Chronic Myelogenous Leukemia / STIR with Double Echo |
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| Research Abstract |
l. Normal Bone Marrow MRI
(1) Optimal Pulse Sequences ; The optimal pulse sequences to image in vivo bone marrow dynamics were STIR with double echo ; TR ; 2000sec, TI 160msec. and TE 20msec. for STIR with shortTE and 120 msec. for longTE.
(2) Normal Bone Marrow MRI ; , STIR with short TE disclosed normal mid-sagittal lumbar vertbrae to be high signal in the peripheral portion of the vertbrae and low signal in the center. The high signal corresponds to red marrow and low signal to yellow marrow. The fatty degeneration took place from lower lumbar vertbra and-ascended cephalad direction.
2. Abnormal Bone Marrow MRI
Eighty-four MRI in various hematological disorders were obtained with STIR with short and long TE. Aplastic anemia showed completely low signal with STIR with short TE in 80%. Multiple myeloma, Chronic myelogenous leukemia, Myelodysplastic syndrome and Myelofibrosis revealed either homogeneous or hetrogeneous high signals with STIR with short TE, while their signals decayed with STIR with long TE in Cronic myelogenous leukemia. STIR with short TE highlights water component and STIR with long TE enhances water T2 component.
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