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1992 Fiscal Year Final Research Report Summary

Information transduction and processing in biological systems

Research Project

Project/Area Number 02045027
Research Category

Grant-in-Aid for international Scientific Research

Allocation TypeSingle-year Grants
SectionUniversity-to-University Cooperative Research
Research InstitutionKagawa Medical School

Principal Investigator

IRINO Shozo  Kagawa Medical School President, 学長 (50033056)

Co-Investigator(Kenkyū-buntansha) WANG J.H.  The University of Calgary Professor, 医学部, 教授
WATANABE M.  The University of calgary Dean, 医学部長
MATSUI Hideki  Kagawa Medical School Associate Professor, 医学部, 助教授 (30157234)
HOSOKAWA Kiyoshi  Kagawa Medical School Vice President, 副学長 (70093698)
HATASE Osamu  Kagawa Medical School Professor, 医学部, 教授 (50033220)
Project Period (FY) 1990 – 1992
KeywordsInternational Exchange Program / Seminar / Information Transduction System
Research Abstract

The human body consists of numerous number of single cells. The communication mechanisms of the biological information in inter- and intra-cellular levels are very important for maintaining the living organisms in physiological conditions. For this communication, numbers of physiological active substances such as hormones, neuro-transmitters, growth factors and so on have important physiological roles. The imbalance and dysfunction of these cross talk factors will lead to various kings of diseases. We have studied the biological information transduction and processing mechanism in collaboration with University of Calgary, Faculty of Medicine in Canada under this grant.
Dr.Irino and Dr.Matsui visited the University of Calgary, Faculty of Medicine to do collaborative works with the scientists in the University of Calgary and also to discuss with the international medical cooperation committee of the University of Calgary on the future plan of the program. The complete agreement between Kagawa side and Calgary side has been made to expand it further in long term scale. Dr.Smith, the newly appointed Dean of Faculty of Medicine, the University of Calgary accepted our invitation to the Kagawa Medical School in April, 1993. Dr.Irino and Dr.Mastui also visited Dr.Mandin, Vice Dean of Clinical Education to discuss on curriculum reformation in the Kagawa Medical School and in the University of Calgary.
Dr.Wang visited the Kagawa Medical School In November, 1992 to do collaborative work on new tyrosine kinase in brain. He was awarded honorable Doctor of Philosophy of the Kagawa Medical School.
Dr.Hatase visited Faculty of Medicine, the University of Calgary on March of 1993 to discuss in detail with the international cooperation committee of the University of Calgary on the definite plan for the future.

  • Research Products

    (26 results)

All Other

All Publications (26 results)

  • [Publications] T.TAOKA: "Induction of differentiation of HL60 cells by protein kinase Cinhitor,K252a." Biochem.Biophys.Res.Commun.170. 1151-1156 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] S.TSUBOI: "Inhibitoin of platelet aggregation by s-(1,2-dicarboxyethyl)-glutathione,intringic tripeptide in liver,heart and lens." Arch.Biochem.Biophys.279. 1100-1101 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] F.YAMAGUCHI: "Insulin like growth factor I(IGF-I)distribution in the tissue and extracellular compartment in different regions of rat brain." Brain Res.533. 344-347 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Y.HATA: "Induction of erythroid differentiation of k562 cells by 4-carbamoylimidazolium 5-olate." Biochem.Pharmacol.42. 2307-2312 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Y.KUBOTA: "Monoclonal antibodies raised against K562 cells reacted with human haematopoietic pluripotent stem cells." Leukemia Res.15. 195-204 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] F.YAMAGUCHI: "Increase of extracellular insulin-like growth factor I(IGF-I)concentration following electrolytical lesion in rat hippocampus." Neurosci.Lett.128. 273-276 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] H.NISHIO: "Identification of testis specific calcineurin β subunit isoform by a monoclonal antibody and detection of a specific six amino acid sequence." Biochem.Biophys.Res.Commun.182. 34-38 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] H.-C.CHENG: "A Synthetic peptide derived from p34^<cdc2> is a specific and efficient substrate of src-family tyrosine kinases." J.Biol.Chem.267. 9248-92 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Y.MINAMOTO: "In vivo microdialysis of amino acid neurotransmitters in the hippocampus in amygdaloid kindled rat." Brain Res.573. 345-348 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] L.J.M.P.Moia: "Identification of a src family protein specifically expressed in rat astrocytes by immunohistochemistry and double immunofluorescent study." Brain Res.585. 283-286 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] H.NISHIO: "The evidence for post-meiotic expression of a testis-specific isoform of a regulatory subunit of calcineurin using a monoclonal antibody." Biochem.Biophys.Res.Commun.187. 828-831 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] O.MIYAMOTO: "Effect of embryonic hippocampal transplantation in amygdaloid kindled rat." Brain Res.

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] M.MIZOGUCHI: "Alzheimer's and Parkinson's Disease" Plenum Press., 485 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] T.Taoka: "Induction of differentiation of HL60 cells by protein kinase C inhibitor, K252a." Biochemical Biophysical Research Communication. 170. 1151-1156 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] S.Tsuboi: "Inhibition of platelet aggregation by s-(1,2-dicarboxyethyl)-glutathione, intringic tripeptide in liver, heart and lens." Archiv Biochemistry Biophysics. 279. 1100-1101 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] F.Yamaguchi: "Insulin-like growth factor I(IGF-I) distribution in the tissue and extracellular compartment in different regions of rat brain." Brain Research. 533. 344-347 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Y.Hata: "Induction of erythroid differentiation of K562 cells by 4-carbamoylimidazolium 5-olate." Biochemical Pharmacology. 42. 2307-2312 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Y.Kubota: "Monoclonal antibodies raised against K562 cells reacted with human haematopoietic Pluripotent stem cells." Leukemia Research. 15. 195-204 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] F.Yamaguchi: "Increase of extracellular insulin-like growth factor I(IGF-I) concentration following electrolytical lesion in rat hippocampus." Neuroscience Letters. 128. 273-276 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] H.Nisio: "Identification of testis specific calcineurin beta subunit isoform by a monoclonal antibody and detection of specific a six amino acid sequence." Biochemical Biophysical Research Communication. 182. 34-38 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] H.-C.Cheng: "A Synthetic peptide derived from p34x^<cdc2> is a specific and efficient substrate of src-family tyrosine kinases." Journal of Biological Chemistry. 267. 9248-9256 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Y.Minamoto: "In vivo microdialysis of amino acid neurotransmitters in the hippocampus in amygdaloid kindled rat." Brain Research. 573. 345-348 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] L.J.M.P.Moia: "Indentification of a src-family protein specifically expressed in rat astrocytes by immunohistochemistry and double immunofluorescent study." Brain Research. 585. 283-286 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] H.Nisio: "The evidence for post-meiotic expression of a testis-specific isoform of a regulatory subunit of calcineurin using monoclonal antibody." Biochemical Biophysical Research communication. 187. 828-831 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] O.Miyamoto: "Effect of embryonic hippocampal transplantation in amygdaloid kindled rat" Brain Research.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] M.Mizobuchi: Plenum Press. Basic, Clinical, and Therapeutic Aspects of Alzheimer's and Parkinson's Disease, vol. 1, 491-494 (1991)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1994-03-24  

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