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1992 Fiscal Year Final Research Report Summary

Analysis of the informations included in the sugar chains of glycoproteins,and studies on their functional mechanisms

Research Project

Project/Area Number 02102007
Research Category

Grant-in-Aid for Specially Promoted Research

Allocation TypeSingle-year Grants
Research InstitutionUniversity of Tokyo

Principal Investigator

KOBATA Akira  Inst.of Med.Sci.,Univ.of Tokyo,Professor, 医科学研究所, 教授 (30030852)

Co-Investigator(Kenkyū-buntansha) AMANO Junko  Inst.of Med.Sci.,Univ.of Tokyo,Research Associate, 医科学研究所, 教務職員 (10159460)
FURUKAWA Kiyoshi  Inst.of Med.Sci.,Univ.of Tokyo,Research Associate, 医科学研究所, 助手 (10190133)
ENDO Tamao  Inst.of Med.Sci.,Univ.of Tokyo,Research Associate, 医科学研究所, 助手 (30168827)
Project Period (FY) 1990 – 1992
KeywordsGlycoprotein / N-Linked sugar chain / O-Linked sugar chain / Fermentation / Adhesive protein / 1L-1beta / Lectin / Signal transduction
Research Abstract

Glycoproteins can be classified into the soluble glycoproteins,which are secreted from the cells and act on target cells at their surfaces,and the membrane bound glycoproteins,in which various cell surface receptors are included. In order to elucidate the functional roles of the sugar chains of these two groups of glycoproteins,we picked up several promising topics out of those investigated in our department during the past decade and classified them into seven groups of project. Followings are the abstracts of the results obtained from the projects.
1. Function of the sugar chains of human chorionic gonadotropin: By compar ative study of desialylated hCG and hLH and the hCG isomer containing NeuAcalpha2*6Gal group,it was confirmed that the sialic acid residues of these glycohormones interact with either receptor or its vicinity and play a role for signal transduction.
2. Role of sugar chains for induction of the differentiation of blood cells and their function: Occurrence of tetra-antennary sugar chain was found essential for the expression of in vivo hormonal action of human erythropoietin(EPO). Another important finding in this category is that a sulfated complex type sugar chain with beta-N-acetylgalactosamine residue in their outer chains binds specifically to 1L-1beta and inhibits its action on T-cells.
In addition to the above projects,studies on the sugar chains of LeuCAM,pocrine egg zona pellucida glycoproteins,and several glycopathologies were performed. Establishment of new techniques of sugar chain study and the interaction mechanism of Aleuria aurantia lectin with fucose are the remaining two projects performed by this study.

  • Research Products

    (116 results)

All Other

All Publications (116 results)

  • [Publications] Katoh,H.,Ohgi,K.,Irie,M.,Endo,T.,and Kobata,A.: "The strueture of the asparagine-linked sugar chamis of bovine brain ribonuclease." Carbohyd.Res.195. 273-293 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Furukawa,K.,Matsuta,K.,Takeuchi,F.,Kosuge,E.,Miyamoto,T.,and Kobata,A.: "Kinetic study on a galactosyptransferase in the B sells of patients with rheumatoid arthritis." International Immunology. 2. 105-112 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Fukumori,F.,Takeuchi,N.,Hagiwara,T.,Ohgayashi,H.,Endo,T.,Kochibe,N.,and Kobata,A.: "Primary structure of a fuiose-specific lectin ohtamed from a washroom,Aleuria aurantia." J.Biochem.Tokyo. 107. 190-196 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Endo,T.,Higashino,K.,Hoda,T.,Imanishi,H.,Muratani,K.,Kochibe,N.,Kobata,A.: "Structures of the asparagine-linked oligosaccherides of an alkaline phosphatese,Kasahara isozyme,purified from amnion cells." Cancer Res.50. 1079-1084 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Hiraizumi,S.,Takasaki,S.,Shiroki,K.,Kochibe,N.,and Kobata,A.: "Transfeetion with fragmeuts of the adenovirus 12gene induces tumorigeniaty-associated alteration of N-linked sugar chains in rot cells." Arch.Biochem.Biophys.280. 9-19 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Amano,J.,Nishimura,R.,Sato,S.,and Kobata,A.: "Altered glycosylation of human chorionic gonadotropin decreases its hormonal activity as determineed by cyclicadenosin 3',5'-monophosphate production in MA-10 cells." Glycobiology. 1. 45-50 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Hiraizumi,S.,Takasaki,S.,Nishihira,T.,Mori,S.,and Kobata,A.: "Comparative study of the N-linked oligosaccharides released from normal human esophogeal epithelium and esophogeal sguavous carcinoma." Jpn.J.Cacer Res.(Gann). 81. 363-371 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Takeuchi,M.,Takasaki,S.,Shinoda,M.,and Kobata,A.: "role of sugar chains in the invitro biological activity of human erythropoietin produced in recombinant chinese hamster orary cells." J.Biol.Chem.265. 1127-12130 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Endo,T.,Kasahara,M.,and Kobata,A.: "Struetures of the asparogine-linked sugar chain of glucose transporter from human crythroeyles" Biochemistry. 29. 9126-9134 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Wold,A.E.,Mestecky,J.,Tomana,M.,Kobata,A.,Ohbayashi,H.,Endo,T.,Edeh,C.S.: "Secretory immunoglobulin A carries oligosaccharide receptors for Escherichia col:Type 1 fibrial leatin." Infeet.Immunity. 58. 3073-3077 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Takano,R.,Nose,M.,Kauno,H.,Nishihira,T.,Hiraizumi,S.,Kobata,A.,and Kyogoku,M.: "Recognition of N-glycosidic carbolyarates on esophageal carcinoma cells by macrophage cell line THP-1" Am.J.Pathol.137. 393-401 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Endo,T.,Nishimura,R.,Teshima,S.,Ohkura,H.,Baba,S.,and Kobata,A.: "Structures of the asparagine-linked sugar chains of human chorionic goradotropin from a patiet with extragonadol perm cell tume" Eur.J.Cancer. 27. 277-280 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Asada,M.,Furukawa,K.,Kantor,C.,Gahmberg,C.G.,and Kobata,A.: "Struetural study of the sugar chains of human leukoayte cell adhesion molecules CD11/CD18." Biochemistry. 30. 1561-1571 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Mori,E.,Takasaki,S.,Hedrick,J.L.,Wararip,N.J.,Mori,T.,and Kobata,A.: "Neutral oligosaccharides structures linked to asparagines of porcine zona pellucida glycoproteins." Biochemistry. 30. 2078-2087 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Taki,T.,Ogura,K.,Rokukawa,C.,hara,T.,Kawakita,M.,Endo,T.,Kobata,A.and Handa,S.: "Had-1, a uridine 5'-diphosphogalactose transport-defective mutant of mouse memmary tumor cell FM3A." Caucer Res.51. 1701-1707 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Nakazawa,K.,Furukawa,K.,Kobata,A.,and Narimatsu,H.: "Characterization of a murine β1→4 galactosyltransterase expressed in COS-1 cells." Env.J.Biochem.196. 363-368 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Hiraizumi,S.,Takasaki,S.,Shiroki,K.,and Kobata,A.: "Altered protein glycosylation of rat 3Y1 cells induced by activatel c-myc gene" Int.J.Cancer. 48. 305-310 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Takasaki,S.,Erickson,R.H.,Kim,Y.S.,Kochibe,N.,and Kobata,A.: "N-linked neutral sugar chains of aminopeptidase N purified from rat small intestinal bruch-bader membrane." Biochemistry. 30. 9102-9110 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kawano,T.,Takasaki,S.,Tao,T.W.,and Kobata,A.: "Alfered glycosylation of β1 integrius associated with reduced adhesireness to fibronectin and laminin." Int.J.Cancer. 53. 91-96 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kodama,S.,Tsujimoto,M.,Tsuruoka,N.,Sugo,T.,Endo,T.,and Kobata,A.: "Role of sugar chains in vitro activity of recombinant human interleukin 5." Enr;J.Biochem.(1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Inoue,N.,Takauchi,M.,Asano,K.,Shimizu,R.,Takasaki,S.,Bobata,A: "Struetures of mucin type sugar chains or human erythropoietin purified from urine and culture medium of recombinant chinese hamster orary cells." Arch.Biochem.Biophys.(1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Fudo,T.,Tsukada,T.,Hiraiwa,M.,Uda,U.,and Kobata,A.: "Purification and characterization of an α-L-fucosidase from Pomaceo canoliculuts." Arch.Biochem.Biophys.(1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Nakaka,N.,Furukawa,K.,Greenwalt,D.E.,Sato,T.,and Kobata,A.: "Struetural study of the sugar chains of CD36 purified from bovine mamnary epithelial cells." Biochemstry. (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kobata,A.: "Glycobiology-A novel field of carbohydrate chemstry" Acc.Chem.Res.(1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ohbayashi,H.,Takenaga,N.,Takenaga,S.,Shiraishi,M.,Kitajima,T.,Endo,T.,Kobata,A.: "Production of monocloral antibodies against oligosaccharides coapled to protein." Carbohydr.Rer.236. 349-356 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Endo,T.,Ohbayashi,H.,Kanazawa,K.,Kochibe,N.,and Kobata,A.: "Carbohydrate binding specificity of immobilized Psathyrella vellatina lection." J.Biol.Chem.267. 707-713 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Endo,T.,Nishimura,R.,Saito,S.,Kanazawa,K.,Nomura,K.,Shii,K.,Baba,S.,Kobata,A.: "Corbohyarate structures of β-core fragment of human chorionic gonadotropin isolated from a pregnant in dividual." Endocrinology.130. 2052-2058 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Hiranaka,T.,Furukawa,K.,Esmon,P,C.,Fournel,M.A.,Sawada,S.,Kato,M.,Kobata,A.: "Comparative study of the sugar chains of factor VIII purified from human plasma and from the calture media of recombinant baby hamster kidney cells." J.Biol.Chem.267. 8012-8020 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Hiraizaumi,S.,Takasaki,S.,Ohuchi,N.,Harada,Y.,Nose,M.,Mori,S.,Kobata,A.: "Alfered glylosylation of membrane glyloproteins associated with human mamnary carcinema." Jpn.J.Caner Res.(Gann). 83. 1063-1072 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kodama,S.,Endo,T.,Tsujimoto,M.,and Kobata,A.: "Characterization of recombinant murine interlenkin 5 expressed in chinese hamster oravy cells." Glycobiology. 2. 419-427 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Amano,J.,Steahl,P.,Berger,G.E.,Kochibe,N.,and Kobata,A.: "Structures of mucin-type sugar chains of the galaetosytransfera & purified from human milk." J;Biol.Chem.266. 11461-11477 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yamamura,K.,Takasaki,S.,Ichihashi,M.,Mishima,Y.,and Kobata,A.: "Increase of sialylated tetraantennary sugar chains in parallel to higher lung-colonizing abilities of mouse melanswa clo" J.Invest.Dermatol.97. 735-741 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kawano,T.,Takasaki,S.,Tao,T.W.,and Kobata,A.: "N-linked sugar chains of mouse B 16 melanoma cells and their low-metastaszing rariant selected by wheat germ agglutinin." Glycobiology. 1. 375-385 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Nagata,Y.,Fukumori,F.,Sakai,H.,Hagiwara,T.,Hiratsuka,Y.,Kochibe,N.,Kobata,A.: "Crystallization and characterization of a lectin obtained from a mushroom, Alenria aurantia." Biochem,Biophys.Acta. 1076. 187-190 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Tsuda,M.,Endo,T.,Sasaki,S.,Masuho,Y.,Kochibe,N.,and Kobata,A.: "Struetural study of the sugar moieties of monoclored antibodies secreated by human-mouse hybridoma." Arch,Biochem,Biophys.291. 339-348 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kodana,S.,Endo,T.,Tsuruoka,N.,Tsujimoto,M.,and Kobata,A.: "Carbohydrate structures of human interlenkin 5 expressed in chinese hamster orary cells." J,Biochem.Tokyo. 110. 693-701 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kobata,A.: "Funetion and pathology of the sugar chains of human immunoglobulin G." Glycobiology. 1. 5-8 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Furukawa,K.and Kobata,A.: "IgG glycosylation" Mol.Imnunol.28. 1333-1340 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Takeuchi,M.and Kobata,A.: "Struetures and functional roles of the sugar chains of human crythropoietins." Glycobiology. 1. 337-346 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kobata,A.and Endo,T.: "Immabilized leetin columms" J.Chromatogr.597. 111-122 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Furukawa,K.and Kobata,A.: "Protein glycosylation" Current Opinion in Biotechnol.3. 554-559 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kobata,A.: "Structures and funnetions of the sugar chains of glycoproteins." Euv.J.Biochem.209. 483-501 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 木幡 陽: "タンパク質への糖鎖付加に関する諸問題" 現代化学. 19. 105-116 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 天野 純子,木幡 陽: "腫瘍の産生するhCGの糖鎖構造とホルモン活性" Bio-medica. 5. 36-41 (1990)

    • Description
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  • [Publications] 木幡 陽: "糖タンパク質ホルモン糖鎖の構造と機能" 化学と工学. 43. 910-913 (1990)

    • Description
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  • [Publications] 遠藤 玉夫,古川 清,木幡 陽: "糖蛋白質糖鎖の分離" 細胞. 22. 25-30 (1990)

    • Description
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  • [Publications] 古川 清,遠藤 玉夫,木幡 陽: "糖蛋白質糖鎖の構造解析" 細胞. 22. 31-38 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 遠藤 玉夫,古川 清,木幡 陽: "細胞外マトリクス蛋白質の糖鎖の意義" 生物物理. 30. 305-316 (1990)

    • Description
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  • [Publications] 木幡 陽: "Glycobiologyの展開" バイオサイエンスとインダストリー. 48. 33-36 (1990)

    • Description
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  • [Publications] 木幡 陽: "糖鎖生物学時代の幕あけ" 蛋白質・核酸・酵素. 36. 775-788 (1991)

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  • [Publications] 木幡 陽: "細胞の悪性化に伴う膜糖蛋白質糖鎖の高分岐化" 化学と生物. 29. 414-415 (1991)

    • Description
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  • [Publications] 木幡 陽: "糖タンパク質糖鎖の構造と機能" 有機合成化学協会誌. 50. 451-463 (1992)

    • Description
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  • [Publications] 木幡 陽: "糖タンパク質糖鎖のはたらき" 化学と教育. 40. 291-295 (1992)

    • Description
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  • [Publications] 木幡 陽: "糖タンパク質のN-結合糖鎖の癌性変化とその臨床応用" 薬学雑誌. 112. 379-396 (1992)

    • Description
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  • [Publications] 木幡 陽: "糖タンパク質糖鎖の構造と機能" 学術月報. 45. 13-20 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kobata,A.,Amano,J.,Mizuochi,T.,and Endo,T.: "Glycobiology" Wiley-Liss,New York, 12 (1990)

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  • [Publications] Kobata,A.: "Glycoprotein Hormones" Serono Symposia,USA, 8 (1990)

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  • [Publications] Kobata,A.,and Furukawa,K.: "Glycocoujugates" Marcel Dekker,Inc.,New York, 37 (1992)

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  • [Publications] Furukawa,K.,and Kobata,A.: "Carbohydrates" Kodansha Scientific Ltd.,Tokyo, 16 (1992)

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  • [Publications] Kobata,A.,and Takasaki,S.: "Cell surface carbohydrates cell development" CRC Press, 24 (1992)

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  • [Publications] Kobata,A.: "Methods Enzynol." Academic Press, (1992)

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  • [Publications] 藤遠 玉夫,山下 克子,木幡 陽: "がんのバイオサイエンス4" 東京大学出版会, 17 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 木幡 陽: "糖鎖工学" 産業調査会・バイオテクノロジー情報センター, (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 木幡 陽: "新生化学実験講座 第3巻" 東京化学同人, 37 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 木幡 陽: "腫瘍マーカー" 富士レビオ, 7 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Furukawa,K.,and Kobata,A.: "Cell surface and extracellular Glycocoujugates" Academic Press, (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 木幡 陽: "分析化学便覧" 丸善, (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Katoh,H.,Ohgi,K.,Irie,M.,Endo,T.,and Kobata,A.: "The structure of the asparagine-linked sugar chains of bovine brain ribonuclease." Carbohyd.Res.195(2). 273-293 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Furukawa,K.,Matsuta,K.,Takeuchi,F.,Kosuge,E.,Miyamoto,T.,and Kobata,A.: "Kinetic study on a galactosyltransferase in the B cells of patients with rheumatoid arthritis." International Immunology. 2(1). 105-112 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Fukumori,F.,Takeuchi,N.,Hagiwara,T.,Ohbayashi,H.,Endo,T.,Kochibe,N.,Nagata,Y.,and Kobata,A.: "Primary structure of a fucosespecific lectin obtained from a mushroom,Aleuria aurantia." J.Biochem.Tokyo. 107(2). 190-196 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Endo,T.,Higashino,K.,Hada,T.,Imanishi,H.,Muratani,K.,Kochibe,N.,and Kobata,A.: "Structures of the asparagine-linked oligosaccharides of an alkaline phosphatase,Kasahara isozyme,purified from FL amnion cells." Cancer Res.50(4). 1079-1084 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hiraizumi,S.,Takasaki,S.,Shiroki,K.,Kochibe,N.,and Kobata,A.: "Transfection with fragments of the adenovirus 12 gene induces tumorigenicity-associated alteration of N-linked sugar chains in rat cells." Arch.Biochem.Biophys.280(1). 9-19 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Amano,J.,Nishimura,R.,Sato,S.,and Kobata,A.: "Altered glycosylation of human chorionic gonadotropin decreases its hormonal activity as determined by cyclic- adenosine 3',5'-monophosphate production in MA-10 cells." Glycobiology. 1(1). 45-50 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hiraizumi,S.,Takasaki,S.,Nishihira,T.,Mori,S.,and Kobata,A.: "Comparative study of the N-linked oligosaccharides released from normal human esophageal epithelium and esophageal squamous carcinoma." Jpn.J.Cancer Res.(Gann). 81(4). 363-371 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kobata,A.: "Function and pathology of the sugar chains of human immunoglobulin G." Glycobiology. 1(1). 5-8 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Takeuchi,M.,Takasaki,S.,Shimada,M.,and Kobata,A.: "Role of sugar chains in the in vitro biological activity of human erythropoietin produced in recombinant Chinese hamster ovary cells." J.Biol.Chem.265(21). 12127-12130 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Endo,T.,Kasahara,M.,and Kobata,A.: "Structures of the asparagine-linked sugar chain of glucose transporter from human erythrocytes." Biochemistry. 29(39). 9126-9134 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Wold,A.E.,Mestecky,J.,Tomana,M.,Kobata,A., Ohbayashi,H.,Endo,T.,and Eden,C.S.: "Secretory immunoglobulin A carries oligosaccharide receptors for Escherichia coli Type 1 fimbrial lectin." Infect.Immunity. 58(9). 3073-3077 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Takano,R.,Nose,M.,Kanno,H.,Nishihira,T.,Hiraizumi,S.,Kobata,A.,and Kyogoku,M.: "Recognition of N-glycosidic carbohydrates on esophageal carcinoma cells by macrophage cell line THP-1." Am.J.Pathol.137. 393-401 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kobata,A.,Amano,J.,Mizuochi,T.,and Endo,T.: "Altered glycosylation of human chorionic gonadotropin in trophoblastic diseases and its use for the diagnosis of choriocarcinoma in "Glycobiology"(UCLA Symp.on Molecular and Cellular Biology,Welply,J.K.and jaworski,E.,eds.)." Wiley-Liss,New York. 111. 115-126 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kobata,A.: "Structures and function of the sugar chains of human chorionic gonadotropin in "Glycoprotein Hormones"(Chin,W.W.and Boime,I.,eds.)." Serono Symposia,USA. 19-26 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Endo,T.,Nishimura,R.,Teshima,S.,Ohkura,H.,Baba,S.,and Kobata,A.: "Structures of the asparagine-linked sugar chains of human chorionic gonadotropin from a patient with extragonadal germ cell tumour." Eur.J.Cancer. 27(3). 277-280 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Asada,M.,Furukawa,K.,Kantor,C.,Gahmberg,C.G.,and Kobata,A.: "Structural study of the sugar chains of human leukocyte cell adhesion molecules CD11/CD18." Biochemistry. 30(6). 1561-1571 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Mori,E.,Takasaki,S.,Hedrick,J.L.,Wardrip,N.J.,Mori,T.,and Kobata,A.: "Neutral oligosaccharide structures inked to asparagines of porcine zona pellucida glycoproteins." Biochemistry. 30(8). 2078-2087 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Taki,T.,Ogura,K.,Rokukawa,C.,Hara,T.,Kawakita,M.,Endo,T.,Kobata,A.,and Handa,S.: "Had-1,a uridine 5'-diphosphogalactose transport-defective mutant of mouse mammary tumor cell FM3A: Composition of glycolipids,cell growth inhibition by lactosylceramide, and loss of tumorigenicity." Cancer Res.51(6). 1701-1707 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Furukawa,K.and Kobata,A.: "IgG galactosylation-Its biological significance and pathology." Mol.Immunol.28(12). 1333-1340 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Nakazawa,K.,Furukawa,K.,Kobata,A.,and Narimatsu,H.: "Characterization of a murine beta1*4galactosyltrans-ferase expressed in COS-1 cells." Eur.J.Biochem.196(2). 363-368 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hiraizumi,S.,Takasaki,S.,Shiroki,K.,and Kobata,A.: "Altered protein glycosylation of rat 3Y1 cells induced by activated c-myc gene." Int.J.Cancer. 48(2). 305-310 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Takasaki,S.,Erickson,R.H.Kim,Y.S.,Kochibe,N.,and Kobata,A.: "N-Linked neutral sugar chains of aminopeptidase N purified from rat small intestinal brush-border membrane." Biochemistry. 30(37). 9102-9110 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kobata,A.and Endo,T.: "Immobilized lectin columns: Useful tools for the fractionation and structural analysis of oligosaccharides." J.Chromatogr.597. 111-122 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hiraizumi,S.,Takasaki,S.,Ohuchi,N.,Harada,Y., Nose,M.,Mori,S.,and Kobata,A.: "Altered glycosylation of membrane glycoproteins associated with human mammary carcinoma." Jpn.J.Cancer Res.(Gann). 83. 1063-1072 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Furukawa,K.and Kobata,A.: "Protein glycosylation." Current Opinion in Biotechnol. 3(5). 554-559 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kodama,S.,Endo,T.,Tsujimoto,,.,and Kobata,A.: "Characterization of recombinant murine interleukin 5 expressed in Chinese hamster ovary cells." Glycobiology. 2(5). 419-427 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kobata,A.: "Structures and functions of the sugar chains chains of glycoproteins." Eur.J.Biochem.209(2). 483-501 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kawano,T.,Takasaki,S.,Tao,T.-W.,and Kobata,A.: "Altered glycosylation of beta1 integrins associated with reduced adhesiveness to fibronectin and laminin." Int.J.Cancer. 53(1). 91-96 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kodama,S.,Tsujimoto,M.,Tsuruoka,N.,Sugo,T., Endo,T.,and Kobata,A.: "Role of sugar chains in the in vitro activity of recombinant human interleukin 5." Eur.J.Biochem.(1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Inoue,N.,Takeuchi,M.,Asano,K.,Shimizu,R.,Takasaki,S.,and Kobata,A.: "Structures of mucin-type sugar chains on human erythropoietin purified from urine and the culture medium of recombinant Chinese hamster ovary cells." Arch.Biochem.Biophys.(1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Endo,T.,Tsukada,T.,Hiraiwa,M.,Uda,U.,and Kobata,A.: "Purification and characterization of an alpha-L-fucosi-dase from Pomacea canaliculata." Arch.Biochem.Biophys.(1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Amano,J.,Staehl,P.,Berger,E.G.,Kochibe,N.,and Kobata,A.: "Structures of mucin-type sugar chains of the galactosyltransferase purified from human milk - Occurrence of the ABO and Lewis blood group determinants." J.Biol.Chem.266(18). 11461-11477 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yamamura,K.,Takasaki,S.,Ichihashi,M.,Mishima,Y.,and Kobata,A.: "Increase of sialylated tetraantennary sugar chains in parallel to the higher lung-colonizing abilities of mouse melanoma clones." J.Invest.Dermatol.97(4). 735-741 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kawano,T.,Takasaki,S.,Tao,T.-W.,and Kobata,A.: "N-Linked sugar chains of mouse B16 melanoma cells and their low-metastasizing variant selected by wheat germ agglutinin." Glycobiology. 1(4). 375-385 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Nagata,Y.,Fukumori,F.,Sakai,H.,Hagiwara,T., Hiratsuka,Y.,Kochibe,N.,and Kobata,A.: "Crystallization and characterization of a lectin obtained from a mushroom,Aleuria aurantia." Biochim.Biophys.Acta. 1076(2). 187-190 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Takeuchi,M.and Kobata,A.: "Structures and functional roles of the sugar chains of human erythropoietins." Glycobiology. 1(4). 337-346 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tandai,M.,Endo,T.,Sasaki,S.,Masuho,Y.,Kochibe,N.,and Kobata,A.: "Structural study of the sugar moieties of monoclonal antibodies secreted by human-mouse hybridoma." Arch.Biochem.Biophys.291(2). 339-348 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kodama,S.,Endo,T.,Tsuruoka,N.,Tsujimoto,M.,and Kobata,A.: "Carbohydrate structures of human interleukin 5 expressed in Chinese hamster ovary cells." J.Biochem.Tokyo. 110(5). 693-701 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ohbayashi,H.,Takenaga,M.,Takenaga,S.,Shiraishi,M.,Kitajima,T.,Endo,T.,and Kobata,A.: "Production of monoclonal antibodies against oligosaccharides coupled to protein." Carbohydr.Res.236. 349-356 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Endo,T.,Ohbayashi,H.Kanazawa,K.,Kochibe,N.,and Kobata,A.: "Carbohydrate binding specificity of immobilized Psathyrella velutina lectin." J.Biol.Chem.267(2). 707-713 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Endo,T.,Nishimura,R.,Saito,S.,Kanazawa,K.,Nomura,K.,Katsuno,,.,Shii,K.,Mukhopadhyay,K.,Baba,S., and Kobata,A.: "Carbohydrate structures of beta-core fragment of human chorionic gonadotropin isolated from a pregnant individual." Endocrinology. 130(4). 2052-2058 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hironaka,T.,Furukawa,K.,Esmon,P.C.,Fournel,M.A.,Sawada,S.,Kato,,.,Minaga,T.,and Kobata,A.: "Comparative study of the sugar chains of factor VIII purified from human plasma and from the culture media of recombinant baby hamster kidney cells." J.Biol.Chem.267(12). 8012-8020 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Nakata,N.,Furukawa,K.,Greenwalt,D.E.,Sato,T.,and Kobata,A.: "Structural study of the sugar chains of CD36 purified from bovine mammary epithelial cells: Occurrence of novel hybrid-type sugar chains containing the Neu5Acalpha2*6GalNAcbeta1*4GlcNAc and the Manalpha 1*2Manalpha1*3Manalpha1*6Man groups." Biochemistry. (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kobata,A.: "Glycobiology - A novel field of carbohydrate chemistry." Acc.Chem.Res.(1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kobata,A.: "Size Fractionation of oligosaccharides." Methods Enzymol.(1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kobata,A.and Furukawa,K.: Marcel Dekker,Inc.,New York. Methods of carbohydrate analysis and structural determination: Chemical and enzymatic methods in"Glycoconjugates: Composition, Structure,and Function"(Allen,H.C.and Kisailus,E.C., eds.)., 33-69 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Furukawa,K.and Kobata,A.: Kodansha Scientific Ltd.,Tokyo. Cell surface carbohydrates-Their involvement in cell adhesion in "Carbohydrates: Synthetic Methods and Applications in Medical Chemistry"(T.Suami,A.Hasegawa and H. Ogura,eds.)., 371-386 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kobata,A.and Takasaki,S.: CRC Press. Structure and biosynthesis of cell surface carbohydrates in "Cell Surface Carbohydrates and Cell Development"(Fukuda,M.,ed.)., 1-24 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Furukawa,K.and Kobata,A.: Academic Press,New York. Use of structural analyses to examine the functions of N-and O-linked sugar chain of glycoprotein in"Cell surface and Extracellular Glycoconjugates: Structure and Function"(Robert P. Mecham and David D.Roberts,eds.)., (1993)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1994-03-24  

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