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1992 Fiscal Year Final Research Report Summary

AN ANALYSIS OF THE ACTUAL STATUS OF SLEEP DISORDERED BREATHING IN PRESENT JAPAN

Research Project

Project/Area Number 02304042
Research Category

Grant-in-Aid for Co-operative Research (A)

Allocation TypeSingle-year Grants
Research Field Respiratory organ internal medicine
Research InstitutionTOKAI UNIVERSITY

Principal Investigator

OHTA Yasuyo  Tokai University, Dpt. of Med., Professor, 医学部, 教授 (90055939)

Co-Investigator(Kenkyū-buntansha) OKADA Tamotsu  Nagoya University, Sch. of Nursery, Professor, 医療技術短期大学部, 教授 (00023771)
KURIYAMA Takayuki  Chiba University, Dpt. of Med., Professor, 医学部, 教授 (20009723)
KUNO Kenshi  Kyoto University, Dpt. of Med., Professor, 医学部, 教授 (70170016)
TOGAWA Kiyoshi  Akita University, Dpt. of Med., Professor, 医学部, 教授 (40009444)
KAWAKAMI Yoshikazu  Hokkaido University, Dpt. of Med., Professor, 医学部, 教授 (10001877)
Project Period (FY) 1990 – 1992
KeywordsEpidemiology / Criteria / Treatment Guideline / Sleep Disordered Breathing / Sleep Apnea Syndrome / Apnea Index / Nasal CPAP / Uvulopalatopharyngoplasty
Research Abstract

For the past three years, we have been involved with this research project. The study consisted of three main sections, which included the epidemiology, the criteria and the treatment modalities for sleep disordered breathing (SDB). In addition, we have had meetings twice a year for the purpose of discussing and future guideline of our project. Fundamentally, the project has been based on the analyses of different questionnaires distributed to subjects for the 3 years to take real SDB morbidity in Japan. Moreover, the final objectives of this expanded study is to propose a better criteria and treatment guideline for SDB, from analyzing questionaires from hundreds of hospitals and institutions throughout Japan.
As a result, we summarize as follows:
1)The morbidity of SDB, especially sleep apnea syndrome (SAS) in Japan, is almost the same as that in North America in accordance with the standard criteria proposed by Stanford group.
2)There is a much higher percentage of patients with milder SDB, especially SAS received less treatment in Japan compared with that in North America. With these 2 findings, it is inferred that a more sophisticated criteria for SAS should be developed, which could better differentiate between treatment-needed vs. treatment-not-needed. For example, the apnea index of 5/hour could be raised to 10/hour. Furthermore, clinical signs and symptoms associated with SAS could be used as criteria for the diagnosis of SDB and SAS.
3)The use of nasal CPAP and uvulopalatopharyngoplasty (UPPP) as treatment modalities for patients with severe SDB and/or SAS is very limited in Japan compared to North America. This finding is unexpected, because nasal CPAP and UPPP have been proven to be a very beneficial treatment for severe cases. Therefore, we consider that it is necessary to establish treatment modality guideline for SDB and/or SAS.
4)This form of research project should be continued to further investigate SDB, a prevalent but still unfamiliar disease in Japan.

  • Research Products

    (13 results)

All Other

All Publications (13 results)

  • [Publications] Y.Ohata et al.: "Prevalence of risk fuctors for sleep apnea in Japan:Apreliminary report" Sleep.

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Y.Takasaki,Y.Ohta et al.: "Changes in diaphragmatic EMG actiuity during Sleep in space" Am Rev Respir Dis.

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] M.Nishimura,Y.Kawakami et al.: "Effeet of the ophylline on brain tissue oxygenation during normoxia and hypoxia in humans" J Appl physiol.

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] C.Miura,T.Takishima et al.: "Effects of posture on flrs-volume curves during normocapnia and hypercapnig in patients with OSA" Thorax. 47. 524-528 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] M.Tanaka,T.Kuriyama et al.: "Effect of sastained hypoxia on ventilatory and heart rateresponses in carotid body-resected humans" Jpn J Appl Physiol. 22. 81-87 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 高崎 雄司,太田 保世他: "睡眠時無呼吸症候群" 肺と心. 39. 40-46 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 太田 保世他: "日本人の睡眠時呼吸障害" 東海大学出版会, 200 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Y.Ohta, et al.: "Prevalence of risk factors for sleep apnea in Japan: A preliminary report" Sleep.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Y.Takasaki, Y.Ohta, et al.: "Changes in diaphragmatic EMG activity during sleep in space" Am Rev Respir Dis.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Y.Akiyama, Y.Kawakami, et al.: "Effect of naloxone on the sensation of dyspnes acute respiratory stress in normal adults" J Appl Physiol.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] M.Nishimura, Y.Kawakami, et al.: "Effect of theophylline on brain tissue oxygenation during normoxia and hypoxia in humans" J Appl Physiol.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] C.Miura, T.Takishima, et al.: "Effects of posture on flow-volume curves during normocapnia and hypercapnia in patients with obstructive sleep apnea" Thorax. 47. 524-528 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] M.Tanaka, T.Kuriyama, et al.: "Effect of sustained hypoxia on ventilatory and heart rate responses in carotid body-resected humans" Jpn J Appl Physiol. 22. 81-87 (1992)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1994-03-24  

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