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1992 Fiscal Year Final Research Report Summary

Study on Autoregulatory Mechanism of Body Fluid with Special Emphasis on Kidney and Hormones

Research Project

Project/Area Number 02304055
Research Category

Grant-in-Aid for Co-operative Research (A)

Allocation TypeSingle-year Grants
Research Field 医学一般
Research InstitutionTokyo Medical and Dental University

Principal Investigator

MARUMO Fumiaki  Tokyo Med. Dent. Univ. Dept. Med. Professor, 医学部, 教授 (00050443)

Co-Investigator(Kenkyū-buntansha) SAITO T  Jichi Med. School Dept.Med. Professor, 教授 (10048994)
KUROKAWA K  Univ. of Tokyo Dept. Med. Professor, 医学部, 教授 (30167390)
ORITA Y  University Medical School Professor, 医学部, 助教授 (70028398)
ENDO H  Univ. of Tokyo Dept. Med. Associate Professor, 医学部, 助教授 (20101115)
IMAI M  Jichi Med. School Dept. Pnarmacol. Professor, 教授 (40049010)
Project Period (FY) 1990 – 1992
Keywordsautoregulation / renal function / hormones / body fluid / mesangium cell / tubular cell / signal transduction / water channel
Research Abstract

To maintain body fluid homeostasis, autoregulatory mechanism including osmolarity, electrolytes, acid-base balance, nutritents, water etc, plays important roles in human body. To elucidate autoregulatory mechanism, especially kidney function and hormone actions, the present research project team was organized. The results revealed the primary structure of a novel vasopressin-sensitive water channel from rat renal collecting duct, interaction of thiazide or amiloride with PTH in stimulating Ca2+ absorption in rabbit connecting tubulus, localization of hormone receptors and their signal transductions along rat nephron, angiotensin-mediated signal transduction in rat glomerular mesangial cells, mesangial function and chloride ions, vasopressin-induced signal transduction of rat medullary collecting duct, NO-induced hypotension and natriuresis/diuresis in rat, structure/function relationship of aldosteron receptor, regulation of proton cotranspoter for drug transport in proximal tubulus, and endothelins-induced signal transduction in vascular endothelial and smooth muscle cells.

  • Research Products

    (19 results)

All Other

All Publications (19 results)

  • [Publications] Fushimi,K.,Uchida,S.,Hara,Y.,Hirata,Y.,Sasaki,S.,Marumo,F.: "Cloning and expression of apical membrane water channel of rat kidney collecting tubule." Nature. 361. 549-552 (1993)

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  • [Publications] Uchida,S.,Sasaki,S.,Furukawa,T.,Hiraoka,M.,Imai,T.,Hirata,Y.Marumo,F.: "Mol*cular cloning of a chloride channel that is regulated by dehydration and expressed predominantly in kidney medulla." J.Biol.Chem.

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  • [Publications] Shimizu,T.,Nakamura,M.,Yoshitomi,K.,Imai,M.: "Interaction of trichlormethiazide or amiloride with PTH in stimulating Ca^<2+> absorption in rabbit CNT." Am.J.Physiol.261. F36-F43 (1991)

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  • [Publications] Shimizu,T.,Naruse,M.,Takeda,M.,Nakamura,M.,Yoshitomi,K.,Imai,M.: "Mechanism of PGE_2-induced cell swelling in distal nephron segments." Am.J.Physiol.263. F824-F832 (1992)

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  • [Publications] Ha,H.,Endou,H.: "Lipid peroxidation in isolated rat nephron segments." Am.J.Physiol.263. F601-F606 (1992)

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  • [Publications] Fushimi,R.,Suminoe,A.,Yasuhara,M.,Suehisa,E.,Matsui,M.,Yamaguchi,G.,Amino,N.,Shin,S.,Orita,Y.,Miyata,K.: "Negative interference by ethamsylate in enzymatic assay of serum creatinine involving peroxidase coupled reaction." Clin.Chem.38. 169-170 (1992)

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  • [Publications] Shinkawa,T.,Yamasaki,F.,Kikuchi,A.,Nakakuki,M.,Nishijima,K.,Uemura,A.,Mizota,M.,Orita,Y.: "Pharmacological properties of a novel highly potent diurectic M-17055, A quinolinone oxime sulfonic acid derivatives." Arznein. 42. 1466-1472 (1992)

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  • [Publications] K.M.Asif Jamil.,Takano,T.,Nakao,A.,Honda,Z.,Shimizu,T.,Watanabe,T.,Kurokawa,K.: "Expression of platelet activating factor receptor in renal tubular cell line(LLC-PK_1)." Biochem.Bophys.Res.Comm.187. 767-772 (1992)

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  • [Publications] Kaname,S.,Uchida,S.,Ogata,E.,Furokawa,K.: "Autocrine secretion of transforming growth factor - beta in cultured rat mesangial cells." Kidney Int.(in press).

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  • [Publications] Ishikawa,S.,Okada,K.,Saito,T.: "pH Dependence of inhibition of arginine vasopressin-induced CAMP production by cellular sodium depletion in rat renal inner medullary collecting duct cells in culture." Endoorinology. 130. 17-22 (1992)

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  • [Publications] Ishikawa,S.,Okada,K.,Saito,T.: "pH Dependence of the action of arginine vasopressin in renal collecting tubule." Am.J.Physiol.262. F784-F792 (1992)

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  • [Publications] Ikenaga,H.,Suzuki,H.,Ishii,N.,Itoh,H.,Saruta,T.: "Role on NO on pressure-natriuresis in Wistar-Kyoto and spontaneously hypertensive rats." Kindney Int.

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  • [Publications] Suzuki,H.,Ikenaga,H.,Hishikawa,K.,Nakaki,T.,Kato,R.,Saruta,T.: "Increases in NO_2/NO_3 excretion in the urine as an indicator of the release of endothelium-derived relaxing factor during elevation of blood pressure." Clin.Sci.82. 631-634 (1992)

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  • [Publications] Komatuda,A.,Wakui,H.,Imai,H.,Nakamoto,Y.,Miura,A.B.,Itoh,H.,Tashima,T.: "Renal localization of the constitutive 73-kDa heat shock protein in normal and PAN rats." Kidney Int.41. 1204-1212 (1992)

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  • [Publications] Matsubara,O.,Kasuga,T.,Marumo,F.,Itoh,H.,Tashima,Y.: "Localization of 90-kDa heat shock protein in the kidney." Kidney Int.28. 830-834 (1990)

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  • [Publications] Saito,H.,Yamamoto,M.,Inui,K.,Hori,R.: "Transcellular transport of organic cation across monolayers of kidney epithelial cell line LLC-PK_1." Am.J.Physiol.262. C59-C66 (1992)

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  • [Publications] Takano,M.,Kato,M.,Takayama,A.,Yasuhara,M.,Inui,K.,Hori,R.: "Transport of procainamide in a kidney epithelial cell line LLC-PK_1." Biochim.Biophys.Acta. 1108. 113-139 (1992)

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  • [Publications] Imai,T.,Hirata,Y.,Emori,T.,Yanagisawa,M.,Masaki,T.,Marumo,F.: "Induction of endothelin-1 gene by angiotensin and vasopressin in endothelial cells." Hypertension. 19. 753-757 (1992)

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  • [Publications] Kubota,T.,Kamada,S.,Hirata,Y.,Imai,T.,Marumo,F.,Aso,T.: "Synthesis and relase of endothelin-1 by human decidual cells." J.Clin.Endocrinol.Metab.75. 1230-1234 (1992)

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Published: 1994-03-24  

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