• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

1991 Fiscal Year Final Research Report Summary

Quantum Theory and Spectroscopy of Proteins as Biomachines

Research Project

Project/Area Number 02305013
Research Category

Grant-in-Aid for Co-operative Research (A)

Allocation TypeSingle-year Grants
Research Field 広領域
Research InstitutionOkazaki National Research Institutes, Institute for Molecular Science

Principal Investigator

KITAGAWA Teizo  Okazaki National Research Institutes / Professor, 分子科学研究所, 教授 (40029955)

Co-Investigator(Kenkyū-buntansha) MIKI Kunio  Tokyo Institute of Technology Institute for Resources and Chemistry Associate Pr, 資源化学研究所, 助教授 (10116105)
KASHIWAGI Hiroshi  Kyushu Institute of Technology Faculty of Information Engineering Professor, 情報工学部, 教授 (10000853)
HATANO Masahiro  Tohoku University Institute for Chemical Reactions Professor, 非水溶液化学研究所, 教授 (50006293)
AKUTSU Hideo  Yokohama National University Faculty of Engineering Professor, 工学部, 教授 (60029965)
MORISHIMA Isao  Kyoto University Faculty of Engineering Professor, 工学部, 教授 (50026093)
Project Period (FY) 1990 – 1991
KeywordsBiomachine / Proteins / Spectroscopy / MO calculation / Protein dynamics
Research Abstract

This cooperative research aims cooperation of theoreticians in basic chemistry and biophysics with experimentalists in biochemistry and spectroscopy. The two kinds of scientists do not see each other in ordinary scientific meetings. In order to create a new concept about proteins which work as biomachines, it is desirable to prepare opportunities for the two kinds of scientists to discuss. Accordingly, we had three meetings during two years. The main subjects are electron and energy transfer in proteins, ab inito MO calculations for large molecules, time-resolved spectroscopy of biological molecules, and dynamics of proteins. Materials treated by the members include various heme proteins, photosynthetic reaction centers, retinoid proteins, various membrane proteins and enzymes. Practical activities and results are published in a separate booklet.

  • Research Products

    (31 results)

All Other

All Publications (31 results)

  • [Publications] S.Hashimoto,Y.Mizutani,Y.Tatsuno,T.Kitagawa: "Resonance Raman characterization of ferric-and ferrylporphyrin π cation radicals and the Fe^<IV>=O stretching frequency" J.Am.Chem.Soc.113. 6742-6549 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] T.Egawa,T.Ogura,R.Makino,Y.Ishimura,T.Kitagawa: "Observation of the O-O stretching Raman band for cytochrome P-450_<cam> under catalytic conditions" J.Biol.Chem.266. 10246-10248 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] M.Natai,Y.Yoneyama,T.Kitagawa: "Unusual CO binding geometry in abnormal subunits of hemoglobin M Boston and Hb M Saskatoon" Biochemistry. 30. 6495-6503 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Y.Mizutani,S.Tokitomi,K.Aoyagi,K.Horitsu,T.Kitagawa: "Resonance Raman study on intact pea phytochrome and its model compounds;Evidence for proton migration during the phototransformation" Biochemistry. 30. 10693-10700 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] T.Ogura,S.Takahashi,K.Shinzawa-Itoh,S.Yoshikawa,T.Kitagawa: "Time-resolved resonance Raman investigation of cytochrome oxidase catalysis:Observation of a new oxygen-isotope sensitive Raman band" Bull.Chem.Soc.Jpn.64. 2901-2907 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] S.Takahashi,T.Ogura,K.Itoh-Shinzawa,S.Yoshikawa,T.Kitagawa: "Observation of the Cu_A-ligand stretching resonance Raman band for cytochrome c oxidase" J.Am.Chem.Soc.113. 9400-9401 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 北川 禎三: "ラマン分光,第4版 実験化学講座 6" 372-388 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 北川 禎三,紙中 庄司: "紫外共鳴ラマン分光による蛋白質の構造研究,分光研究 40" 193-206 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] S. Sato, M. Asano-Someda, T. Kitagawa: "Time-resolved resonance Raman spectra of free-base octaethylporphyin in the S_1 and T_1 states" Chem. Phys. Lett.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] S. Kaminaka, T. Kitagawa: "Time-resolved UV resonance Raman study on Bohr effects of hemoglobin" J. Am. Chem. Soc.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] N. Kitajima, K. Fujiwara, C. Fujimoto, Y. Moro-oka, S. Hashimoto, T. Kitagawa, K. Toriumi, K. Tatsumi, A. Nakamura: "A new model for dioxygen binding in hemocyanin. Synthesis, characterization, and molecular structure of the mu-eta^2 : eta^2 peroxo dinuclear copper (II) complexes, [Cu(HB(3, 5-R_2pz)_3)]_2(O_2) (R=iPr and Ph)" J. Am. Chem. Soc.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] S. Takahashi, T. Ogura, K. Itoh-Shinzawa, S. Yoshikawa, T. Kitagawa: "Observation of the Cu_A-ligand stretching resonance Raman band for cytochrome c oxidase" J. Am. Chem. Soc.113. 9400-9401 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] N. Kitajima, T. Koda, S. Hashimoto, T. Kitagawa, Y. Moro-oka: "Synthesis and characterization of the dinuclear copper (II) complexes [Cu(HB(3, 5-Me_2pz)_3)]_2X (X=O^<2->, (OH)_2^<2->, CO_3^<2->, O_2^<2->)" J. Am. Chem. Soc.113. 5664-5671 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] T. Ogura, S. Takahashi, K. Shinzawa-Itoh, S. Yoshikawa, T. Kitagawa: "Time-resolved resonance Raman investigation of cytochrome oxidase catalysis : Observation of a new oxygen-isotope sensitive Raman band" Bull. Chem. Soc. Jpn.64. 2901-2907 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] K. Imai, K. Fushitani, G. Miyazaki, K. Ishimori, T. Kitagawa, Y. Wada, H. Morimoto, I. Morishima, D. T. -b Shih, J. Tame: "Site-directed mutagenesis in haemoglobin. Functional role of tyrosine-42 (C7) alpha at the alpha1-beta2 interface" J. Mol. Biol.218. 769-778 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Y. Mizutani, S. Tokutomi, K. Aoyagi, K. Horitsu, T. Kitagawa: "Resonance Raman study on intact pea phytochrome and its model compounds ; Evidence for proton migration during the phototransformation" Biochemistry. 30. 10693-10700 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] M. Nagai, Y. Yoneyama, T. Kitagawa: "Unusual CO binding geometry in abnormal subunits of hemoglobin M Boston and Hb M Saskatoon" Biochemistry. 30. 6495-6503 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] T. Egawa, T. Ogura, R. Makino, Y. Ishimura, T. Kitagawa: "Observation of the O-O stretching Raman band for cytochrome P-450_<cam> under catalytic conditions" J. Biol. Chem.266. 10246-10248 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] K. Kamogawa, T. Kitagawa: "Evidence for direct intermolecular interactions as an origin of the hydration shifts of the C-H stretching vibrations ; 1, 4-dioxane/water system" Chem. Phys. Lett.179. 271-276 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] V. Fidler, T. Ogura, S. Sato, K. Aoyagi, T. Kitagawa: "Resonance Raman study on photoreduction of iron-porphyrins : a novel insigh into the ligandaided process" Bull. Chem. Soc. Jpn.64. 2315-2322 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] S. Hashimoto, Y. Mizutani, Y. Tatsuno, T. Kitagawa: "Resonance Raman characterization of ferric-and ferrylporphyrin pi cation radicals and the Fe^<IV>=O stretching frequency" J. Am. Chem. Soc.113. 6542-6549 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Y. Mizutani, K. Kamogawa, T. Kitagawa, A. Shimizu, Y. Taniguchi, K. Nakanishi: "Solution structures and phase separation in fluoroalcohol/water mixtures ; A study with Raman difference and ^<13>C NMR spectroscopy" J. Phys. Chem.95. 1790-1794 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] M. Nakagawa, A. Maeda, T. Ogura, T. Kitagawa: "Identification of the long-lived L' species of bacteriorhodopsin to the N intermediate by Raman/absorption quasi-simultaneous measurements" J. Mol. Struct.242. 221-234 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] T. Ogura, S. Takahashi, K. Shinzawa, S. Yoshikawa, T. Kitagawa: "Observation of the Fe^<II>-O_2 stretching Raman band for compound A of cytochrome oxidase at room temperature" J. Am. Chem. Soc.112. 5630-5631 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Y. Mizutani, S. Hashimoto, Y. Tatsuno, T. Kitagawa: "Resonance Raman pursuit of the change from Fe^<II>-O_2 to Fe^<III>-OH via Fe^<IV>=O in autoxidation of ferrous iron-porphyrin" J. Am. Chem. Soc.112. 6809-6814 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] S. Tokutomi, Y. Mizutani, E. Anni, T. Kitagawa: "Resonance Raman scattering from large pea phytochrome at ambient temperature : Difference in chromophore protonation between red-and far-red light absorbing forms" FEBS Lett.269. 341-344 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] N. Kitajima, H. Fukui, Y. Moro-oka, Y. Mizutani, T. Kitagawa: "A synthetic model for dioxygen binding site of non-heme proteins. X-ray structure of Fe (OBz) (MeCN) [HB(3, 5-iPr_2pz)_3] and resonance Raman evidence for reversible formation of peroxo adduct" J. Am. Chem. Soc.112. 6402-6403 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] T. Egawa, Y. Imai, T. Ogura, T. Kitagawa: "Resonance Raman study on mutant cytochrome P-450 obtained by site directed mutagenesis" Biochim. Biophys. Acta. 1040. 211-216 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] T. Ogura, V. Fidler, Y. Ozaki, T. Kitagawa: "Alcohol catalyzed photoreduction of iron porphyrin complexes revealed by resonance Raman and absorption spectroscopies" Chem. Phys. Lett.169. 457-459 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] K. Kamogawa, T. Kitagawa: "A new device for Raman difference spectroscopy and its application to observe frequency shifts due to isotope mixing" J. Phys. Chem.94. 3916-3921 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] S. Kaminaka, T. Ogura, T. Kitagawa: "Time-resolved ultraviolet resonance Raman study of the photolysis of carbonmonoxy hemoglobin : Relaxation of the globin structure" J. Am. Chem. Soc.112. 23-27 (1990)

    • Description
      「研究成果報告書概要(欧文)」より

URL: 

Published: 1993-03-16  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi