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1992 Fiscal Year Final Research Report Summary

Neuronal connections of module structures in the brain

Research Project

Project/Area Number 02454113
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field 神経解剖学
Research InstitutionKYOTO UNIVERSITY

Principal Investigator

MIZUNO Noboru  Kyoto Univ., Fac. Med., Prof., 医学部, 教授 (10025596)

Co-Investigator(Kenkyū-buntansha) NOMURA Sakashi  Kyoto Univ., Fac. Med., Technol., Prof., 医療技術短期大学部, 教授 (60034188)
KONISHI Akira  Kyoto Univ., Fac. Med., Technol., Prof., 医療技術短期大学部, 教授 (00025660)
SHIGEMOTO Ryuichi  Kyoto Univ., Fac. Med., Res. Assoc., 医学部, 助手 (20221294)
TAKADA Masahiko  Kyoto Univ., Fac. Med., Lecturer, 医学部, 講師 (00236233)
KANEKO Takeshi  Kyoto Univ., Fac. Med., Assoc. Prof., 医学部, 助教授 (90177519)
Project Period (FY) 1990 – 1992
KeywordsGlutamate / Receptor / Glutaminase / Striatum / Amygdala / Cerebral cortex / Cerebellum / Ventral tegmental area
Research Abstract

1. In the rat striatum, glutaminase-like immunoreactivity was found in non-cholinergic neurons. Axon terminals containing glutaminase were observed with mosaic patterns; glutaminase immunoreactivity in neuropil was more marked in the "patches" than in the "matrix".
2. In the neo- and mesocortex of the rat, glutaminase-like immunoreactivity was found in pyramidal cells, but not in most GABAergic, cholinergic and peptidergic nonpyramidal cells.
3. Distributions of the mRNAs for metabotropic glutamate receptors, mGluRu and mG1uR2, were examined in the rat brain by in situ hybridization.
4. The projections from the ventral tegumental area to the cerebellum in the rat were found to be segregated into the dopaminergic projections to the cerebellar cortex and the non-dopaminergic projections to the deep cerebeallr nuclei.
5. The central amygdaloid nucleus of the cat was found to send projection fibers to the globus pallidus and substantia nigra pars compacta, possibly exerting limbic influences upon forebrain motor mechanisms.

  • Research Products

    (12 results)

All Other

All Publications (12 results)

  • [Publications] Kaneko,Takeshi: "Masaic distribution of phosphate-activated glutaminase-like immuno reactivity in the rat striatum" Neuroscience. 49. 329-345 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Shigemoto,Ryuichi: "Distribution of the mRNA for a metabotropic glutamate receptor(mGluR1)in the central nervous system:an in situ hybridization study in adult and developing rat" J.comp.Neurol.322. 121-135 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kaneko,Takeshi: "Paucity of glutaminase-immuno reactive nonpyramidal neurons in the rat cerebral cortex" J.comp.Neurol.322. 181-190 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Shinonaga,Yasuhide: "Direct projections from the central amygdalord nucleus to the globus pallidus and substantia nigra in the cat" Neuroscience. 51. 691-703 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ikai,Yoshiaki: "Dopamineroic and non-dopaminergic neurons in the ventral tegmental area of the rat project,respectively,to the cerebellar cortex and deep cerebellar nuclei" Neuroscience. 51. 719-728 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ohishi,Hitoshi: "Distribution of the mRNA for a metabotropic glutamate receptor(mGluR2)in the central nervous system of the rat" Neuroscience.

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kaneko, Takeshi: "Mosaic distribution of phosphate-activated glutaminase-like immunoreactivity in the rat striatum" Neuroscience. 49. 329-345 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Shigemoto, Ryuichi: "Distribution of the mRNA for a metabo-tropic glutamate receptor (mGluR1) in the central nervous system: an in situ hybridization study in adult and develoing rat" J. comp. Neurol.322. 121-135 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kaneko, Takeshi: "Paucity of glutaminase-immunoreactive nonpyramidal neurons in the rat cerebral cortex" J. comp. Neurol.322. 181-190 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Shinonaga, Yasuhide: "Direct projections from the central amygdaloid nucleus to the globus pallidus and substantial nigra in the cat" Neuroscience. 51. 691-703 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ikai, Yoshiaki: "Dopaminergic and non-dopaminergic neurons in the ventral tegmental area of the rat project respectively to the cerebellar cortex and deep cerebellar nuclei" Neuroscience. 51. 719-728 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ohishi, Hitoshi: "Distribution of the mRNA for a metabo-tropic glutamate receptor (mGluR2) in the central nervous system of the rat" Neuroscience. (1993)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1994-03-24  

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