1992 Fiscal Year Final Research Report Summary
HTLV-I infection and immune disorders : A role of HTLV-I tax gene for mesenchymal cell transformation.
| Project/Area Number |
02454225
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
内科学一般
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| Research Institution | Rheumatology Division, Institute of Medical Science, St Marianna University (1991-1992)
Tokyo Women's Medical University (1990) |
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Principal Investigator |
NISHIOKA Kusuki St. Marianna Univ.:Professor of Medicine, 医学部, 教授 (60049070)
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| Co-Investigator(Kenkyū-buntansha) |
YAMAMOTO Kazuhiko Univ. of Tokyo :MD, 医学部, 講師 (80191394)
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| Project Period (FY) |
1990 – 1992
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| Keywords | HTLV-I associated arthropathy / synovial hyperplasia / proto oncogene / colony formation / genomic transfer / loss of contact inhibition / retrovirus / rheumatoid arthritis |
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| Research Abstract |
The etiological factor(s) of rheumatoid arthritis (RA) have been well unknown.
The salient features is invasive synovial proliferation lead to bone erosion.
We have revealed the relationship of the HTLV-I infection to chronic arthropathy through out the study of clinical and molecular biological analysis and established the following results.
1) The patient with arthropathy in HTLV-I infection was proposed as one of the subsets of RA.
2) The presence and the expression of proviral HTLV-I genome in synovial cell derived from HAAP patient were clarified.
3) HTLV-I tax expression causes synovial transformation and hyperplasia in either human synovial or transgenic mice. Therefore, we demonstrate that HTLV-I tax gene is the first exogeneous retroviral gene which causes resembling rheumatoid arthritis.
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Research Products
(12 results)
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[Publications] Y.IWAKURA,M.TOSU,E.YOSHIDA,M.TANIGUCHI,K.SATO,I.KITAJIMA,K.NISHIOKA,K.YAMAMOTO,T.TAKEDA,M.HATANAKA,H.YAMAMOTO,T.SEKIGUCHI: "Induction of Inflammatory Arthropathy Resembling Rheumatoid Arthritis in Mice Transgenic for HTLV-I" Science. 253. 1026-1029 (1991)
Description
「研究成果報告書概要(和文)」より
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[Publications] Y.IWAKURA, M.TOSU, E.YOSHIDA, M.TANIGUCHI, K.SATO, I.KITAJIMA, K.NISHIOKA, K.YAMAMOTO, T.TAKEDA, M.HATANAKA, H.YAMAMOTO, T.SEKIGUCHI: "Induction of Inflammatory Arthropathy Resembling Rheumatoid Arthritis in Mice Transgenic for HTLV-I" Science. 253. 1026-1029 (1991)
Description
「研究成果報告書概要(欧文)」より
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