1991 Fiscal Year Final Research Report Summary
Mechanisms of Restenosis Following Coronary Angioplasty and its Prevention
| Project/Area Number |
02454259
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Yamagata University School of Medicine (1991)
Kyushu University (1990) |
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Principal Investigator |
TOMOIKE Hitonobu Yamagata University, School of Medicine, Professor, 医学部, 教授 (90112333)
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| Co-Investigator(Kenkyū-buntansha) |
YAMAKI Michiyasu Yamagata University, School of Medicine, Instructor, 医学部, 助手 (40191217)
IKEDA Kozue Yamagata University, School of Medicine, Instructor, 医学部, 助手 (30184419)
TONOOKA Ichiro Yamagata University, School of Medicine, Assist. Professor, 医学部, 講師 (70164001)
KUBOTA Isao Yamagata University, School of Medicine, Assist. Professor, 医学部, 講師 (30161673)
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| Project Period (FY) |
1990 – 1991
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| Keywords | atherosclerosis / coronary artery stenosis / PTCA / coronary artery spasm / restenosis / platelet / serotonin / X-ray irradiation |
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| Research Abstract |
Although the percutaneous transluminal coronary angioplasty (PTCA) has commonly been applied to patients with coronary artery disease, high incidence of restenosis close to 50%, following the procedure remains one of the most serious complications. The goal of the present study was to elucidate the factors, mechanisms and prevention related to the accelerated proliferation of the intima, injured by a balloon catheter in Gottingen miniature pigs. Semisynthetic diet added cholesterol 2% and sodium chlorate was given to induce hypercholesterolemia and to augment the atherosclerotic process. We disclosed several interesting phenomena as follows ; (1) Spontaneous coronary constriction was noted after the balloon-induced intimal injury and reached gradually by 5 minutes the maximum level (60% narrowing). The augmented constriction was partly prevented by intravenous administration of heparin 3000 units or ketanserin. Exaggerated response to serotonin remained for 2 but not 4 weeks. (2) X-ray irradiation per se enhanced responses to serotonin. Intimal thickening was noted 4 weeks after the irradiation. (3) Denudation plus X-ray irradiation augmented the constrictive responses to serotonin as well as the thickening of the intima. Additional PTCA attenuated the extent of serotonin-induced constriction while this procedure augmented the speed of intimal thickening. Accordingly, the present animal model may provide keys to elucidate the mechanisms of ensuing restenosis related to the angioplasty. Remedies to prevent accelerated intimal thickening will be explored by these basic studies.
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[Publications] Tomoike H, Egashira K, Yamamoto Y, Shimokawa H, Hayashi Y, Yamada A, Nanasawa K, Mitsuoka W, Egashira S, Kuga T, Tagawa H, Nakamura M: "Cascade of pathophysiological events leading to spasm of coronary arteries." Regulation of Coronary Blood Flow. Springer-Verlag. 254-258 (1991)
Description
「研究成果報告書概要(欧文)」より
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