1992 Fiscal Year Final Research Report Summary
Development of Hybrid Type Compound Artificial Skin
| Project/Area Number |
02454303
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
General surgery
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| Research Institution | KYOTO UNIVERSITY |
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Principal Investigator |
ISSHIKI Nobuhiko Faculty of Med. Plastic Surgery Professor, 医学部, 教授 (50025566)
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| Co-Investigator(Kenkyū-buntansha) |
SUZUKI Shigehiko Faculty of Med. Plastic Surgery Assist. Professor, 医学部, 助教授 (30187728)
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| Project Period (FY) |
1990 – 1992
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| Keywords | Artificial Skin / Skin Equivalent / Wound Dressings / Cultured Skin / Collagen / Augmentation Materials |
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| Research Abstract |
1)Bilayer artificial skin
A bilayer artificial skin, composed of an inner layer of collagen sponge and an outer silicone layer, had been developed. Since then, several improvements have been made in this artificial skin to solve some problems and to eliminate some drawbacks. Good results were obtained by using this modified type, which suggests further and wide application in the near future.
2)Cultured artificial skin
Three types of artificial skin containing keratinocytic component. In order to get continuous keratinocytic layers on artificial skin dermis (ASD), pores of its top surface were filled with type I collagen gel, Matrigel, or fibroblasts. Of three material, keratinocytic layer on fibroblasts-ASD complex is the most similar to normal epidermis because keratinocytes formed continuous layers, well proliferated and properly differentiated.
3)Use of ASD for subcutaneous embedding material.
ASD including poly-L-lactic acid fibers has been developed for the material of soft tissue augmentation. In addition. ASD including cultured cartilageous membrane has been being investigated.
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[Publications] Matsuda,K.,Suzuki,S.,Isshiki,N.,Yoshioka,K.,Wada,R.,Hyon,S.-H.and Ikada,Y.: "Evaluation of a bilayer artificial skin capable of sustained release of an antibiotic." Biomaterials. 13. 119-122 (1992)
Description
「研究成果報告書概要(和文)」より
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[Publications] Matsuda, K., Suzuki, S., Isshiki, N., Yosioka, K., Okada, T. and Ikada, Y.: "Influence of glycosaminoglycan on the collagen sponge component of a bilayer artificial skin." Biomat.11. 351-355 (1990)
Description
「研究成果報告書概要(欧文)」より
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[Publications] Matsuda, K., Suzuki, S., Isshiki, N., Yoshioka, K., Wada, R., Okada, T., Hyon, S.-H. and Ikada, Y.: "A bilayer "artificial skin" capable of sustained release of an antibiotic." Br. J. Plast. Surg.44. 142-146 (1991)
Description
「研究成果報告書概要(欧文)」より
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[Publications] Matsuda, K., Suzuki, S., Isshiki, N., Yoshioka, Okada, T., Hyon, S.-H. and Ikada, Y.: "Augmentation of soft tissue with biodegradable materials: Experimental investigation." J. Jpn. P. R. S.11. 629-641 (1991)
Description
「研究成果報告書概要(欧文)」より
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[Publications] Matsuda, K., Suzuki, S., Isshiki, N., Yoshioka, K., Wada, R., Hyon, S.-H. and Ikada, Y.: "Evaluation of a bilayer artificial skin capable of sustained release of an antibiotic." Biomat. 13. 119-122 (1992)
Description
「研究成果報告書概要(欧文)」より
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