1992 Fiscal Year Final Research Report Summary
Studies for clinical application of missile therapy for cancer.
| Project/Area Number |
02454318
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Digestive surgery
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| Research Institution | KYOTO PREFECTURAL UNIVERSITY OF MEDICINE |
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Principal Investigator |
TAKAHASHI Toshio KYOTO PREFECTURAL UNIVERSITY OF MEDICINE, 第一外科, 教授 (50079828)
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| Co-Investigator(Kenkyū-buntansha) |
HAGIWARA Akeo Hagiwara,Dept. of Surgery Assistant, 第一外科, 助手 (90198648)
YAMAGUCHI Toshiharu Yamaguchi,Dept. of Surgery Lecturer, 第一外科, 講師 (90111327)
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| Project Period (FY) |
1990 – 1992
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| Keywords | Missile Therapy / Monoclonal Antibody / Chimeric Antibody / Colon Cancer / HAMA |
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| Research Abstract |
Monoclonal antibody-drug conjugate,A7-NCS,was applied for 80 patients with colorectal and pancreatic cancer, including metastasis of liver, lung and peritoneum. Fifty-four patients with colon cancer, fifteen patients with postoperative liver metastasis of colorectal cancer and one patient with advanced pancreatic cancer ware given A-NCS intra-arterially. Two patients with postoperative lung metastasis of colon cancer were injected intra-venously and one patient with postoperative peritoneal metastasis of colon cancer was given it intraperitoneally. Three patients with liver metastasis showed evidence of tumor reduction on CT scan and three claimed pain relief. Postoperative survival of the patients with distant metastasis exhibited slightly higher survival rate in the patients with A7-NCS, as compared with the patients without A7-NCS. There was no serious adverse effect in the patients given A7-NCS.Human anti-body(HAMA)was detected in all patients given the conjugate. Repeated injections of A7-NCS for several consecutive days following the first injection brought about the same A pattern as the first injection. Chimeric monoclonal antibody A7 and its conjugate chimeric A7-NCS were successfully produced.
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[Publications] Noguchi, A., Takahashi, T., yamaguchi, T., Kitamura, K., Noguchi, A., Tsurumi, HI., Takashina, K., Macda, H.: "Enhanced tumor localization of monoclonal antibody by treatment with kininase II inhibition and angiotensin II." Jpn J. Cancer Res.83. 240-243 (1992)
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[Publications] Otsuji, E., Yamaguchi, T., Yamaguchi, M., Koyama, K., Imanishi, J., Yamaoka, N., Takahashi, T.: "Expression of cell surface antigen detected by the monoclonal antibody A7 in pancreatic carcinoma cell lines." Surgery Today Jpn J surg. 22. 351-256 (1992)
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[Publications] Otsuji E., Yamaguchi, T., Yamaoka, N., Yamaguchi, N., Imanishi, J., Takahashi, T.: "biodistribution of monoclonal antibody A7 and its F(ab')2 fragment in athyimic nude mice bearing human pancreatic carcinoma." J Sung Oncl. 50. 173-178 (1992)
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[Publications] Kitamura, K., Takahashi, T., Miyagaki, T., Yamaoka, N., Tsurumi, H., Otsuji, E., Kamiguchi, M., Noguchi A., Yamaguchi, T.: "Efficacy and specificity of a monoclonal antibody-drug conjugate in chemotherapy by intratumoral injection." Jpn J Cancer Res. 83. 769-774 (1992)
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[Publications] Noguchi, A., Takahashi, T., Kitamura, K., Takakura, Y., Hashida, M., Sczaki, H.: "Preparation and properties of the immunoconjugate composed of anti-human colon cancer monoclonal antibody and mitomycin C-dextran conjugate" bioconjugate chemistry. 3. 132-137 (1992)
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[Publications] Hagiwara, A., Takahashi, T., Kojima, O., Sawai, K., Yamaguchi, T., Yamane, T., Taniguchi, H., Kitamura, K., Noguchi, A., Seiki, K., Sakakura, C.: Lancet. 339. 629-631 (1992)
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[Publications] Kitamura, K., Takahashi, T., Yamaguchi, T., Hagiwara, A., Taniguchi, H., Tanaka, H., Hashimoto, S.: "Postoperative TNP-induced lactic acidosis." Lancet, letter to cditor, October. 31. 1097-1098 (1992)
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[Publications] Kitamura, K., Takahashi, T., Kotani, T., Miyagaki, T., Yamaoka, N., Tsurumi, H., Noguchi, A., Yamaguchi, T.: "Local administration of monoclonal antibody-drug conjugate; A new strategy to reduce the local recurrence of colorectal cancer." Cancer Res. 52. 6128-6133 (1992)
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