1992 Fiscal Year Final Research Report Summary
Pathophysiological and pathological evaluation of developing lung hypoplasia in the human fetus.
| Project/Area Number |
02454385
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Kyushu University |
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Principal Investigator |
TSUKAMOTO Naoki Faculty of Medicine, Kyushu University Associate Professor, 医学部, 助教授 (30038830)
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| Co-Investigator(Kenkyū-buntansha) |
SUEISHI Katsuo Faculty of Medicine, Kyushu University Professor, 医学部, 教授 (70108710)
SATOH Shoji Faculty of Medicine, Kyushu University Lecturer, 医学部, 助手 (00225947)
MAEDA Hirotaka Faculty of Medicine, Kyushu University Senior Lecturer, 医学部, 講師 (20199631)
KOYANAGI Takashi Faculty of Medicine, Kyushu University Associate Professor, 医学部, 助教授 (30136452)
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| Project Period (FY) |
1990 – 1992
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| Keywords | Human fetus / Hypoplastic lung / Surfactant apoprotein / Radial alveolar count / Immunohistochemistry / Lung growth / Lung maturation / Non-immunologic hydrops fetalis |
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| Research Abstract |
For the past 3 years, we studied the pathophysiological and pathological changes of the fetuses with lung hypoplasia, and also we attempted to establish prenatal evaluation and obstetrical management of fetuses at risk of developing lung hypoplasia.
In the fetuses with lung hypoplasia, we made it clear that, 1) there existed structual or differentiational abnormalties of epithelial alveolar cells, 2) the development of hypoplastic lung in fetuses with pleural effusion may depend on the time of initial diagnosis and the length of presence of pleural effusion, 3) Serum growth inhibiting factors to epithelial alveolar type II cells may be present. As for these findings, it is necessary for understanding the pathogenesis of lung hypoplasia to evaluate the growth and differentional potential of alveolar type II cells.
On the contrary, we established prenatal evaluation and obstetrical management of fetuses at risk of developing lung hypoplasia using lung area measurement by ultrasound. In addition, we attempted to evaluate the age-related development of lung compressibility using M-mode ultrasound, and we made clear that lung compressibility was a good indicator of lung interstitial cells. These nomograms of lung area and lung compressibility may be useful in evaluating both lung growth and maturation, as well as in the direct obstetrical management of fetuses at risk of developing lung hypoplasia.
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