1992 Fiscal Year Final Research Report Summary
Possible involvement of gonadotropins in the tumorigenesis of human ovarian neoplasms
| Project/Area Number |
02454386
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Wakayama Medical College |
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Principal Investigator |
NAKANO Ryosuke Wakayama Medical College Dept of Obstet & Gynecol, Professor, 医学部, 教授 (50030854)
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| Co-Investigator(Kenkyū-buntansha) |
NISHIMORI Keiji Wakayama Medical College Dept of Obstet & Gynecol, Assistant, 医学部, 助手 (40237748)
KOBAYASHI Mitsuko Wakayama Medical College Dept of Obstet & Gynecol, Assistant, 医学部, 助手 (70195816)
YAMOTO Mareo Wakayama Medical College Dept of Obstet & Gynecol, Assistant Professor, 医学部, 助教授 (80106541)
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| Project Period (FY) |
1990 – 1992
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| Keywords | Ovarian neoplasm / FSH / LH / Receptor |
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| Research Abstract |
The binding of human follicle-stimulating hormone (hFSH)and human luteinizing hormone (hLH) to ovarian tumor specimens from 29 patients was analyzed. The specific binding of hFSH were demonstrated in three tumors of epithelial origin (serous cystadenoma and mucinous cystadenoma) and in two of sex cord-stromal origin (theca cell tumor and granulosa cell tumor). The hLH and hFSH binding characteristics of the ovarian tumors were similar to those of the normal ovarian tissue. The surface-autoradiographic study revealed that the binding sites for gonadotropins were localized in the stromal tissue. In patients with ovarian tumors which possess gonadotropin receptors, relatively high estraiol (E_2) and progesterone (P_4) concentrations were found in peripheral or ovarian venous blood. The E2 and P4 levels in peripheral and ovarian venous blood were measured in 45 postemenopausal women with ovarian neoplasms. The steroid levels were compared with the values in postmenopausal women without ovarian tumors. In peripheral or ovarian venous blood, relatively high E2 and P4 concentration were found in some patients with ovarian tumors. Furthermore, two of 7 postmenopausal women with epithelial ovarian tumors responded to the hCG loading test. In addition, E2 was localized not only in the interstitial cells, but also in the tumor cells. The results suggest that gonadotropins may play a role in the growth and differentiation of a certain type of human ovarian neoplasms.
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