1991 Fiscal Year Final Research Report Summary
Endogenous neurotoxins to produce parkinsonism
| Project/Area Number |
02670363
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Neurology
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| Research Institution | Dep Neurology, Jichi Medical School |
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Principal Investigator |
YOSHIDA M. Jichi Medical School, Dep Neurology, Professor, 医学部, 教授 (70048966)
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| Co-Investigator(Kenkyū-buntansha) |
OGAWA M. Same as Above, associate, 医学部, 助手 (50194452)
SUZUKI K. Same as Above, Assistant Professor, 医学部, 講師 (80187723)
NIIJIMA K. Same as Above, Assistant Professor, 医学部, 講師 (80150613)
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| Project Period (FY) |
1990 – 1991
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| Keywords | Parkinsonism / Endogenous neurotoxins / Tetrahydroisoquinoline / Monkeys / Long term administration |
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| Research Abstract |
We have examined the effect of chronic administration of a probable endogenous dopaminergic neurotoxin, tetrahydroisoquinoline (TIQ, 20mg/kg per day, s. c. for up to-104 days), on squirrel monkeys. Chronically administered TIQ produced motor symptoms similar to parkinsonism in squirrel monkeys even after 7 days' discontinuation of TIQ and the symptoms were alleviated remarkably by levodopa treatment. Biochemical analysis of the brains of TIQ-treated monkeys revealed significant decrease in dopamine (DA) and total biopterin (BP) concentrations, and tyrosine hydroxylase (TH) activity in the substantia nigra. Morphological changes of the substantia nigra of the mice were also analysed. The effect of long-term administration of N-methyl-TIQ on aged monkeys was described.
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[Publications] Toshimitsu Niwa,Naohito Takeda,et al.: "Presence of 2-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoqunoline an d1,2-dimethyl 6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline,novel endogenous amines,parkisonian and normal human brains." Biochem.Biophys.Res.Commun.177. 603-609 (1991)
Description
「研究成果報告書概要(和文)」より
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[Publications] Toshimitsu Niwa,Hideo Yoshizumi,et al.: "Endogenous synthesis of N-methyl-1,2,3,4-tetrahydroisoquinoline,a precursor of N-methylisoquinolonium ion,in the brains of primates with parkisonism after systemic administration of 1,2,3,4-tetrahydroisoquinoline." J.of Chromatography. 533. 145-151 (1990)
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「研究成果報告書概要(和文)」より
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[Publications] T. Niwa, N. Takeda, H. Yoshizumi, A. Tatematsu, M. Yoshida, Philippe Dostert, M. Naoi and T. Nagatsu: "Presence of 2-methyl-6, 7-dyhydroxy-1, 2, 3, 4-tetrahydroisoquinoline and 1, 2-dimethyl-6, 7-dihydroxy-1, 2, 3, 4-tetrahydroisoquinoline, novel endogenous amines, in parkinsonian and normal human brains." Biochem. Biophys. Res. Commun. 177. 603-609 (1991)
Description
「研究成果報告書概要(欧文)」より
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[Publications] T. Niwa, N. Takeda, H. Yoshizumi, A. Tatematsu, S. Matsuura, M. Yoshida, M. Naoi and T. Nagatsu: "Endogenous synthesis of N-methyl-1, 2, 3, 4-tetrahydroisoquinoline, a precursor of N-methyl-isoquinolinium ion, in the brains of primates with parkinsonism after systemic administration of 1, 2, 3, 4-tetrahydroisoquinoline." J. of Chromatography. 533. 145-151 (1990)
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「研究成果報告書概要(欧文)」より
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