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1993 Fiscal Year Final Research Report Summary

Cooperation and information exchange with European countries.

Research Project

Project/Area Number 03042012
Research Category

Grant-in-Aid for international Scientific Research

Allocation TypeSingle-year Grants
SectionSpecial Cancer Research
Research InstitutionUniversity of Tokyo

Principal Investigator

KUROKI Toshio  Institute of Medical Science, University of Tokyo, Professor, 医科学研究所, 教授 (90006073)

Co-Investigator(Kenkyū-buntansha) NIKAIDO Osamu  Faculty of Pharmaceutical Sciences, Kanazawa University, 薬学部, 教授 (60019669)
SEKI Shuji  Institute of Cellular and Molecular Biology Okayama University Medical School, 医学部, 教授 (50032884)
TANAKA Kiyoji  Institute for Molecular and Cellular Biology Osaka University, 細胞生体工学センター, 教授 (80144450)
HANAOKA Fumio  The Institute of Physical and Chemical Research (RIKEN), 主任研究員 (50012670)
MAKI Hisaji  Institute of Molecular and Cellular Bioscience University of Tokyo, 分子細胞生物学研究所, 助教授 (20199649)
許 南浩  東京大学, 医科学研究所, 助教授 (70173573)
ISHIKAWA Takatoshi  Faculty of Medicine, University of Tokyo, 医学部, 教授 (30085633)
SEKIGUCHI Mutsuo  Medical Institute of Bioregulation, Kyushu University, 生体防御医学研究所, 教授 (00037342)
HUH Nam-ho  Institute of Medical Science, University of Tokyo
Project Period (FY) 1991 – 1993
KeywordsInternational Exchange Program / French-Japanese Collaborative Program in Cancer Research / German-Japanese Collaborative Program in Cancer Research / Oncogenes / Tumor Suppressor Genes / Signal Transduction / DNA Repair / Cancer Metastasis
Research Abstract

In the fiscal year of 1993, the German-Japanese Workshop was held on 2-4 September 1993 at Institute of Cell Biology, Essen University, Essen, Germany. The workshop was entitled "Molecular and cellular aspects of carcinogenesis - DNA repair and its genes - ". From Japan following scientists participated by the support of this grant : T.Kuroki, T.Ishikawa, N.Huh, H.Maki (Univ. of Tokyo), F.Hanaoka (Riken), O.Nikaido (Kanazawa Univ.), K.Tanaka (Osaka Univ.), S.Seki (Okayama Univ.) and M.Sekiguchi (Kyushu Univ.). The French Japanese workshop was held on November 1-2, 1993 in Kanazawa under the title of "Tumor progression and molecular basis of oncogenesis", in which 12 French scientists and 11 Japanese scientists participated.
In addition to the above collaborative programs, following five scientists were sent to Europe to exchange information and materials : M.Seiki (Kanazawa Univ.), K.Koike (Cancer Institute), M.Shibuya (Univ. of Tokyo), T.Watanabe (Univ. of Tokyo) and Y.Nozawa (Gifu Univ.).

  • Research Products

    (16 results)

All Other

All Publications (16 results)

  • [Publications] Kuroki,T.: "Why are human cells resistant to malignant cell transformation in vitro?" Japan.J.Cancer Res.84. 1091-1100 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Sakumi K.: "Cloning and expression of cDNA for a human enzyme that hydrolyzes 8-Oxo-dGTP,a mutagenic substrate for DNA synthesis." J.Biol.Chem.268. 23524-23530 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Nakatsuru,Y.: "O^6-Methylguanine-DNA methyltransferase protects against nitros-amine-induced hepatocarcigenesis." Proc.Natl.Acad.Sci.USA. 90. 6468-6472 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Huh,N.: "Isolation and characterization of a novel hair follicle-specific gene,hacl-1." J.Inv.Dermatol.(in press). (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Sugasawa,K.: "Cell-free repair of UV-damaged simian virus 40 chromosomes in human cell extracts." J.Biol.Chem.268. 9098-9104 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Satokata,I.: "Genomic characterization of the human DNA excision repair-controlling gene XPAC." Gene. 136. 345-348 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Seki,S.: "Activity gel and activity blotting methods for detecting DNA-modifying(repair)enzymes." J.Chromatogr.618. 147-166 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Matsunaga,T.: "Establishment and characterization of a monoclonaly,antibody recognizing the dewar isomers of(6-4)photoproducts." Photochem.Photobiol.57. 934-940 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kuroki, T.: "Why are human cells resistant to malignant cell transformation in vitro ?" Jpn. J. Cancer Res.84. 1091-1100 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Sakumi, K.: "Cloning and expression of cDNA for a human enzyme that hydrolyzes 8-Oxo-dGTP, a mutagenic substrate for DNA synthesis." J.Biol.Chem.268. 23524-23530 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Nakatsuru, Y.: "O^6-Methylguanine-DNA methyl transference protects against nitrosamine-induced hepatocarcinogenesis." Proc.Natl.Acad.Sci.USA. 90. 6468-6472 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Huh, N.: "Isolation and characterization of a novel hair follicle-specific gene, hacl-1." J.Invest.Dermatol.(in press). (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Sugasawa, K.: "Cell-free repair of UV-damaged simian virus 40 chromosomes in human cell extracts." J.Biol.Chem.268. 9098-9104 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Satokata, I.: "Genomic characterization of the human DNA excision repair-controlling gene XPAC." Gene. 136. 345-348 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Seki. S.: "Activity gel and activity blotting methods for detecting DNA-modifying (repair) enzymes." J.Chromatogr.618. 147-166 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Matsunaga, T.: "Establishment and characterization of a monoclonal antibody recognizing the dewar isomers of (6-4)photoproducts." Photochem.Photobiol.57. 934-940 (1993)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1995-02-07  

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