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1993 Fiscal Year Final Research Report Summary

Information Exchange on Cancer Research with North American Countries.

Research Project

Project/Area Number 03042013
Research Category

Grant-in-Aid for international Scientific Research

Allocation TypeSingle-year Grants
SectionSpecial Cancer Research
Research InstitutionInstitute of Medical Science, University of Tokyo

Principal Investigator

YAMAGUCHI Nobuo  Institute of Medical Science, University of Tokyo, Professor, 医科学研究所, 教授 (90012723)

Co-Investigator(Kenkyū-buntansha) HAMADA Hirofumi  Cancer Chemotherapy Center, 癌化学療法センター, 部長 (00189614)
KOUNO Kimitoshi  Oita Medical University, 助教授 (00153479)
TSUKUMA Hideaki  Center for Adult Diseases, Osaka, 主幹
TAKAHASHI Takashi  Aichi Cancer Center Reserach Institute, 研究所, 室長 (50231395)
TANIGUCHI Naoyuki  School of Medicine, Osaka University, 医学部, 教授 (90002188)
YOSHIKI Takashi  School of Medicine, Hokkaido University, 医学部, 教授 (60220612)
IKEUCHI Taturou  Medical Research Institute, Tokyo Medical and Dental University, 難治疾患研究所, 助教授 (90041839)
YOSHIDA Mituaki  Institute of Medical Science, University of Tokyo, 医科学研究所, 教授 (80012607)
ISHIBASHI Masahide  Aichi Cancer Center Research Institute, 部長 (70029776)
SIBUYA Masabumi  Institute of Medical Science, University of Tokyo, 医科学研究所, 教授 (10107427)
KATAOKA Tooru  School of Medicine, Kobe University, 医学部, 教授 (40144472)
CHIDA Kazuhiro  Insititute of Medical Science, University of Tokyo, 医科学研究所, 助手 (00192188)
NODA Tetuo  Cancer Institute, 癌研究所, 部長 (10183550)
FUJISAWA Jun-ichi  Institute of Medical Science, University of Tokyo, 医科学研究所, 助教授 (40181341)
NAKABEPPU Yuusaku  Medical Institute of Bioregulation, Kyusyu University, 生体防御医学研究所, 助手 (30180350)
TAKAHASHI Rei  Faculty of Medicine, Kyoto University, 医学部, 助教授 (60144565)
SASAKI Takuya  School of Medicine, Kobe University, 医学部, 助手 (40241278)
Project Period (FY) 1991 – 1993
KeywordsInformation exchange / Oncogene / Tumor virus / Tumor promoter / Tumor suppressor gene / Cancer cells / Growth control / Transcriptional regulation
Research Abstract

This research project is to exchange information between groups of high research activity in Japan and those in North American countries.
The research fields of this project were as follows.
1.Oncogene research
2.Viral Oncogenesis
3.Tumor promotion and suppression
4.Diagnostic techniques and cancer therapy
Under this program from 1991 to 1993 fiscal year, total 49 Japanese scientists were sent to United State of America and Canada to attend Annual Meeting on oncogene, Cancer Cell meeting, Keystone Symposia, Papillomavirus Workshop, Annual Meeting on AIDS and HTLV, AACR Special Conferences, Workshop on Biology of Lung Cancer, DNA tumor virus meeting, General Morters Cancer Foundation International Symposium, Cold Spring Harbor Meeting on Eukaryotic DNA Replication, FASEB Summer Research Conference, The Joint-Meeting of American Societies of Biochemistry, Molecular Biology, and Immunology, etc. and also visited universities and institutes to exchange information.
Scientists in Japan, which is geologically remote from developed countries, feel informational retardation. International co-operative studies in progress or in planning, need lively discussions on experimental arrangements.
Face-to-face discussions also facilitate international exchange of research materials. Therefore, this research grant contributed greatly not only for the development of the research of the Japanese grant recipients but also for the development of the research of those who came into touch with them.
The individual results under this program have been published in scientific journals, and a part of the information were also published on the "Bioscience News".

  • Research Products

    (16 results)

All Other

All Publications (16 results)

  • [Publications] Yamamoto,K.(Shibuya,M.): "Characterization of the promoter region of the human c-kit proto-oncogene" Jpn.J.Cancer Res.84. 1136-1144 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Gotoh,N.(Sibuya,M.): "Epidermal growth factor receptor-mutant lacking the autophosphorylation sites induces phosphorylation of Shc and association of Shc with Grb2/Ash,and retains mitogenic activity." Proc.Natl.Acad.,Sci.USA. 91. 167-171 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ookawa,K.(Takahashi,R.): "Reconstitution of the RB gene suppresses the growth of small-cell lung carcinoma cells carrying multiple genetic alterations." Oncogene. 8. 2175-2181 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Habuchi,T.(Takahashi,R.): "Metachronous multifocal development of urothelial cancers by intraluminal seeding." The Lancet. 1993. 1087-1088 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Habuchi,T.(Takahashi,R.): "Accumulated allelic losses in the development of invasive urothelial cancer." Int.J.Cancer. 53. 579-584 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Takaishi,K.(Sasaki,T.): "Involvement of Rho p21 small GTP-binding protein and its regulator in the HGF-induced cell motility." Oncogene. 9. 273-279 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Suzuki,T.(Fujisawa,J.): "A trans-activator tax of human T-cell leukemia virus type 1 binds to NF-κB p50 and serum response factor(SRF)and associates with enhancer DNAs of the NF-κB site and CArG box." Oncogene. 8. 2391-2397 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Tanimura,A.(Fujisawa,J.): "A new regulatory element that augments for the tax-dependent enhancer of human T-cell leukemia virus type 1 and cloning of cDNAs encoding its binding proteins." J.Virol.67. 5375-5382 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yamamoto, K. (Shibuya, M.): "Characterization of the promoter region of the human c-kit proto-oncogene." Jpn. J. Cancer Res.84. 1136-1144 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Gotoh, N. (Sibuya, M.): "Epidermal growth factor receptor-mutant lacking the autophosphorylation sites induces phosphorylation of Shc and association of Shc with Grb2/Ash, and retains mitogenic activity." Proc.Natl.Acad.Sci.USA. 91. 167-171 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ookawa, K. (Takahashi, R.): "Reconstitution of the RB gene suppresses the growth of small-cell lung carcinoma cells carrying multiple genetic alterations." Oncogene. 8. 2175-2181 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Habuchi, T. (Takahashi, R.): "Metachronous multifocal development of urothelial cancers by intraluminal seeding." The Lancet. 1993. 1087-1088 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Habuchi, T. (Takahashi, R.): "Accumulated allelic losses in the development of invasive urothelial cancer." Int. J. Cancer. 53. 579-584 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Takaishi, K. (Sasaki, T.): "Involvement of Rho p21 small GTP-binding protein and its regulator in the HGF-induced cell motility." Oncogene. 9. 273-279 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Suzuki, T. (Fujisawa, J.): "A transactivator tax of human T-cell leukemia virus type 1 binds to NF-kappaB p50 and serum response factor (SRF) and associates with enhancer DNAs of the NF-kappaB site and CArG box." Oncogene. 8. 2391-2397 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tanimura, A. (Fujisawa, J.): "A new regulatory element that augments for the tax-dependent enhancer of human T-cell leukemia virus type 1 and cloning of cDNAs encoding its binding proteins." J.Virol.67. 5375-5382 (1993)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1995-02-07   Modified: 2020-04-13  

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