Development of next generation ventricular assist system and study of long-term assisted circulation

1994 Fiscal Year Final Research Report Summary

• Project/Area Number: 03404041
• Research Category: Grant-in-Aid for General Scientific Research (A)
• Allocation Type: Single-year Grants
• Research Field: Thoracic surgery
• Research Institution: National Cardiovascular Center Research Institute
• Principal Investigator: TAKANO Hisateru National Cardiovascular Center Research Institute, Artificial Organs, Director, 人工臓器部, 部長 (60028595)
• Co-Investigator(Kenkyū-buntansha): KITOH Yoshitsugu National Cardiovascular Center Hospital, Cardiac Surgery, Director, 心臓外科, 部長 ; MASUZAWA Toru National Cardiovascular Center Research Institute, Artificial Organs, Research A, 人工臓器部, 室員 (40199691) ; TATSUMI Eisuke National Cardiovascular Center Research Institute, Artificial Organs, Laboratory, 人工臓器部, 室長 (00216996) ; NAKATANI Takeshi National Cardiovascular Center Research Institute, Biomedical Engineering, Labor, 生体工学部, 室長 (60155752) ; TAENAKA Yoshiyuki National Cardiovascular Center Research Institute, Artificial Organs, Laboratory, 人工臓器部, 室長 (00142183)
• Project Period (FY): 1991 – 1994
• Keywords: Left ventricular assist system / Abdominally placed blood pump / Impedance / portable control drive unit / インピーダンス法 / 制御駆動装置

Research Abstract

We have developed an implantable left ventricular assist system (LVAS) for small sized adult patients. The pump made of segmented polyether poly-urethane was pneumatic driven diaphragm type, which was designed to be positioned in the left abdominal wall. Nine of them were sacrificed after 4 to 18 weeks in good physical condition. The electrical impedance-based monitoring and control system (Z system) was developed for adequate monitoring and automatic control. The performance of the implanted pump was well monitored and the full-fill to full-empty drive was well controlled by the Z system. In conclusion, this LVAS is promising for clinical use.

Research Products

• [Publications] Nakatani T,et al.: "Development of implantable left ventricular assist system : Evaluation of blood pump" Jpn J Artif Organs. 20 (4). 1336-1340 (1991)
  • Description: 「研究成果報告書概要(欧文)」より
• [Publications] Nakatani T,et al.: "An abdominally placed, implantable left ventricular assist system for longterm use" Trans Am Soc Artif Intern Organs. 38. M631-M633 (1992)
  • Description: 「研究成果報告書概要(欧文)」より
• [Publications] Nakatani T,et al.: "An implantable left ventricular assist system with an electrical impedance monitoring" ASAIO Journal. 39. M644-M648 (1993)
  • Description: 「研究成果報告書概要(欧文)」より
• [Publications] Nakatani T,et al.: "Ventricular assist system and Cardiomyoplasty as treatments for profound heart failure" Jpn J Artif Organs. 22 (2). 300-305 (1993)
  • Description: 「研究成果報告書概要(欧文)」より
• [Publications] Anai H,et al.: "Development of continuous monitoring and control system of artificial heart by measuring electrical impedance in a blood chamber with automatic calibration mechanism" Jpn J Artif Organs. 22 (3). 766-769 (1993)
  • Description: 「研究成果報告書概要(欧文)」より
• [Publications] Nakatani T.et al.: "Abdominally-placed implantable left ventricular assist system (LVAS) with a continuous monitoring system" Heart Replacement Artificial Heart. 4. 357-359 (1993)
  • Description: 「研究成果報告書概要(欧文)」より
• [Publications] Nakatani T.et al.: "Development of an implantable left ventricular assist system for bridge to heart transplant" Jpn J Artif Organs. 23 (3). 637-640 (1994)
  • Description: 「研究成果報告書概要(欧文)」より