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1993 Fiscal Year Final Research Report Summary

Clinical Application of Functional Brain Cortical Mapping Using Magnetoencephalography and Electroencephalography

Research Project

Project/Area Number 03404042
Research Category

Grant-in-Aid for General Scientific Research (A)

Allocation TypeSingle-year Grants
Research Field Cerebral neurosurgery
Research InstitutionTOHOKU UNIVERSITY

Principal Investigator

YOSHIMOTO Takashi  University School of Medicine, Professor, 医学部, 教授 (50091765)

Co-Investigator(Kenkyū-buntansha) NAKASATO Nobukazu  Kohnan Hospital, Medical Doctor, 医師 (80207753)
KAYAMA Takamasa  Tohoku University School of Medicine, Lecturer, 医学部, 講師 (50142972)
Project Period (FY) 1991 – 1993
KeywordsMagnetoencephalography / Functional cortical map / Somatosensory evoked response / Auditory evoked response / Visually evoked response / SQUID / Dipole model / Epileptic spike
Research Abstract

We developed a MRI-linked whole head magnetoencephalography (MEG) system as a tool of non-invasive functional brain mapping. In 20 healthy subjects, 80 patients with intracranial structural lesions and 4 patients with intractable seizures, neuromagnetic fields were measured over the entire head, using a helmet shaped 66 channel MEG system.
First, we measured somatosensory evoked field (SEF), auditory evoked field (AEF), and visually evoked field (VEF). We localized generators of above brain activities, using a multiple dipole model with a best-fitting sphere for each subject's head. Finally, the dipoles were superimposed on 3-D MRI.SEF for median and tibial nerve stimuli localized the contralateral central sulcus. AEF for tones localized bilateral superior temporal planes. VEF localized calcarine fissure contralateral to the stimulated half visual field. Positions of the sources were precisely on the responsible cortical surface, with standard deviation of 2-4 mm, either with or without structural lesions.
Second, in patients with epilepsy, interictal epileptic discharges were measured by means of both MEG and EEG.We observed two dipole patterns bilaterally in two cases. These dipolar patterns overlap each other across the midline. A two dipole model estimated "spike" or "wave" dipoles in bilateral neocortices, unilateral neocortex and contralateral mesial temporal structure, or bilateral mesial temporal structures. In the other 2 cases, single dipole pattern appeared on unilateral hemisphere only ; these spike or wave hipoles were estimated within one lobe. The whole head MEG system is useful to localize multifocal epileptic discharges, as well as to evaluate signal propagation between bilateral hemispheres.
In summary, MEG localized cortical function non-invasively, with exceptionally high spatial resolution confirmed by our MRI-linked system. This technique was useful for conventional and intravascular neurosurgery, as well as for stereotaxic radiosurgery.

  • Research Products

    (22 results)

All Other

All Publications (22 results)

  • [Publications] 中里信和: "MEGの基礎と臨床(1)-原理と計測方法-" 臨床放射線. (印刷中). (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 中里信和: "MEGの基礎と臨床(2)-誘発反応による大脳皮質機能マッピング-" 臨床放射線. (印刷中). (1994)

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      「研究成果報告書概要(和文)」より
  • [Publications] 中里信和: "MEGの基礎と臨床(3)-自発脳磁界とMEGの将来-" 臨床放射線. (印刷中). (1994)

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      「研究成果報告書概要(和文)」より
  • [Publications] 中里信和: "脳機能局在と磁気脳波(MEG)" 臨床神経心理. 5(印刷中). (1994)

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  • [Publications] 中里信和: "てんかん術前診断法としての脳磁図(MEG)と脳電図" 臨床脳波. 36. 80-82 (1994)

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  • [Publications] 中里信和: "脳磁界計測の新展開-ヘルメット型SQVID-" 新医療. 2. 70-71 (1994)

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  • [Publications] 中里信和: "脳磁図(Magnetoencephalography)の進歩" 綜合臨床. (印刷中). (1994)

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  • [Publications] 中里信和: "磁気脳波(MEG)の臨床応用" 神経研究の進歩. 38(印刷中). (1994)

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  • [Publications] 中里信和: "ヘルメット型脳磁計による聴覚誘発反応の測定" 日本生体磁気学会雑誌. 6. 28-29 (1993)

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  • [Publications] 藤田智: "後脛骨神経刺激による短潜時体性感覚誘発磁界" 日本生体磁気学会雑誌. 6. 144-145 (1993)

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  • [Publications] 真渓歩: "64ch Whole Cortex SQUID Systemを用いたファントム内の2つの信号源の推定" 日本生体磁気学会雑誌. 6. 16-17 (1993)

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  • [Publications] 畑中啓作: "パターンリバーサル刺激による視覚誘発脳磁波" 日本生体磁気学会雑誌. 6. 152-153 (1993)

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  • [Publications] 中里信和: "ヘルメット型脳磁計による脳機能地図" 日本医用画像工学雑誌. 11. 499-504 (1993)

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  • [Publications] 中里信和: "視覚誘発MEG" Clinical Neuroscience. 11. 204-205 (1993)

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  • [Publications] 中里信和: "てんかんと磁気脳波(MEG)-手術のための脳機能地図-" BME. 6. 41-47 (1992)

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  • [Publications] N.Nakasato: "Simultaneous MEG and ECoG of spontaneous seizures and comparison with MEG and ECoG of auditroy evoked response" Biomagnetism:Clinical aspects,Elsevier,Amsterdam. 83-86 (1992)

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  • [Publications] N.Nakasato: "Localization and quantification of the human epileptic spike zone using MEG,EEG,MRI,and evoked responses with validation by ECoG." Biomagnetism:Clinical aspects,Elsevier,Amsterdam. 79-82 (1992)

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  • [Publications] K.Hatanaka: "Visual evoked magentic fields with red-black- and green-black pattern reversal stimulations." Biomagnetism:Clinical aspects,Elsevier,Amsterdam. 197-200 (1993)

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  • [Publications] N.Nakasato: "Clinical application of the whole head MEG : Auditory evoked response in patients with intracranial structural lesions." Proceedings of the 9th International Conference on Biomagnetism. Elsevier, Amsterdam. (in press). (1994)

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      「研究成果報告書概要(欧文)」より
  • [Publications] S.Fujita: "Short latency somatosensory evoked field for tibial nerve stimulation : rotation of dipole pattern over the whole head." Proceedings of the 9th International Conference on Biomagnetism, Elsevier, Amsterdam. (in press). (1994)

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  • [Publications] N.Nakasato: "The whole head magnetoencephalogram : localization of bilateral sources for unilaterally stimulated auditory evoked response." Electroencephalogr Clin Neurophysiol. 87. S26 (1993)

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  • [Publications] N.Nakasato: "Dipole rotation phenomenon in the short latency somatosensory evoked magnetic field for tibial nerve stimulation." Electroencephalogr Clin Neurophysiol. (in press). (1994)

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Published: 1995-03-27  

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