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1993 Fiscal Year Final Research Report Summary

Significance of central mechanism of calcium regulation in responses to environmental stresses

Research Project

Project/Area Number 03454136
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field 環境生理学(含体力医学・栄養生理学)
Research InstitutionKYUSHU UNIVERSITY

Principal Investigator

AOU Shuji  KYUSHU UNIV., Fac. Med., ASSOC.PROF., 医学部, 助教授 (40150908)

Co-Investigator(Kenkyū-buntansha) KATAFUCHI Toshihiko  KYUSHU UNIV., Fac. Med., ASSIST.PROF., 医学部, 助手 (80177401)
SHIMIZU Nobuaki  SHIMIZU UNIV., Fac. Technol., ASSOC.PROF., 工学部, 助教授 (50019634)
Project Period (FY) 1991 – 1993
KeywordsStress / stress-responses / central mechanisums of calcium regulation / calcium homeostasis / stress-induced hypocalcemia / autonomic nervous system / hypothlamus
Research Abstract

1. Etiology of stress-induced hupocalcemia : Muscarinic antagonist, gastric vagotomy, gastrin release inhibitors or histamine H_2 receptor antagonists diminished the immobilization (IMB) -induced hypocalcemia. The concentration of serum gastrin increased significantly during IMB.Either an antrectomy (removal of the source of gastrin) or a fundectomy (depriving the origin of gastric histamine and gastric acid) was also sufficient for eliminating IMB-induced hypocalcemia. These findings suggest that the antrum and the fundus of the stomach play essential roles in IMB-induced hypocalcemia through the vagus-induced release of gastrin and histamine.
2. Hypothalamic involvement in stress-induced hypocalcemia : Bilateral lesions of the ventromedial nucleus of the hypothalamus (VMH), but not those of the paraventricular hypothalamic nucleus or the lateral hypothalamic area, eliminated immobilization (IMB)-induced hypocalcemia, and electrical stimulation of the VMH decrease the blood calcium level.
3. Hypothalamic linkage of stress-induced hypocalcemia and gastric lesions are closely related and are also influenced by behavioral responsiveness in a strain dependent manner. VMH lesion diminished or attenuated stress-induced hypocalcemia, gastric lesions, and behavioral despair, while the PVN has an opposite effect.
4. Hypothalamic control of blood calcium homeostasis : Stimulation studies revealed that the LHA and the PVN have a hypocalcemic function which is mediated, at least n part, bby the vagus nerve innervating the stomach and the thyroid/parathyhroid glands, respectively.
5. Central effect of parathyroid hormone : Intracerebroventricular injection of PTH prevented urethan-induced hypocalcemia. Hypothalamic injection of PTH prevented urethan-induced hypocalcemia. Hypothalamic injection of PTH also showed a hypercalcemic effect. PTH inhibited activity of VMH neurons through postsynaptic mechanism mediated by PTH receptors.

  • Research Products

    (24 results)

All Other

All Publications (24 results)

  • [Publications] Scott,T.R.: "Gustatory neural coding in the amygdala of the alert macaque monkey." J.Neurophysiol.69. 1810-1820 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ma,J.: "Gastric vagus mediates immobilization-induced hypocalcemia in rats." Am.J.Physiol.(Regulatory Integrative Comp.Physiol.34). 265. R609-R614 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Aou,S.: "Hypothalamic involvement in stress-induced hypocalcemia in rats." Neurosci.Lett.158. 197-200 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Aou,S.: "The stomach is the etiologic organ for immobilization-induced hypocalcemia in rats." Am.J.Physiol.(Regulatory Integrative Comp.Physiol.34). 265. R1376-R1379 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Oka,T.: "Intracerebroventricular injection of interleukin-1 beta induces hyperalgesia in rats." Brain Res.624. 61-68 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ma,J.: "Hypothalamic stimulation induces vagally mediated hypocalcemia in the rat." Brain Res.Bull.33. 65-69 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ma,J.: "Linkage of stress-induced hypocalcemia,gastric lesions and emotional behavior in Wistar Kyoto rats." Am J Physiol(Regulatory Integrative Comp Physiol). (in press).

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Aou,S.: "Hypothalamic linkage in stress-induced hypocalcemia,gastric damage,and emotional behavior in rats." Am.J.Physiol.(Regulatory Integrative Comp.Physiol.). (in press).

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Aou,S.: "The effect of B-HT 920,a dopamine D2 agonist,on bar-press feeding in the monkey." Physiol.Behav.(in press).

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 粟生修司: "ヒトの摂食行動のメカニズムの基礎." JJPEN. 15. 195-200 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 粟生修司: "摂食の病態生理." こころの科学. 52. 21-25 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 粟生修司: "環境ストレス反応における中枢性カルシウム調節機構の意義." 病態生理. 12. 984-986 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 粟生修司: "視床下部によるカルシウム代謝調節とそのストレス応答." 福岡医学誌. 85. 1-4 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 粟生修司: "ストレス-生理学的立場から:中枢性カルシウム調節機構とそのストレス応答." 脳と精神の医学. (印刷中).

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 粟生修司: "神経内分泌免疫学(井村裕夫,堀哲郎,松村繁 編)" 朝倉書店, 312 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Scott, T.R.: "Gustatory neural coding in the amygdala of the alert macaque monkey" J.Neurophysiol. 69. 1810-1820 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ma, J.: "Gastric vagus mediates immobilization-induced hypocalcemia in rats" Am. J.Physiol (Regulatory Integr. Comp. Physiol. 34). 265. R604-R614 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Aou, S.: "Hypothalamic involvement in stress-induced hypocalcemia in rats" Neurosci. Lett. 158. 197-200 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Aou, S.: "The stomach is the etiologic organ for immobilization-induced hypocalcemia in rats" Am. J.Physiol (Regulatory Integr. Comp. Physiol. 34). 265. R1376-R1379 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Oka, T.: "Intracerebroventricular injection of interleukin-1 beta induces hyperalgesia in rats" Brain Res. Bull. 33. 65-69 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ma, J.: "Hypothalamic stimulation induces vagally mediated hypocalcemia in the rat" Brain Res. Bull. 33. 65-69 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ma, J.: "Linkage of stress-induced hypocalcemia, gastric lesions and emotional behavior in Wistar Kyoto rats" Am. J.Physiol (Regulatory Integr. Comp. Physiol). in press.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Aou, S.: "Hypothlamic linkage in stress-induced hypocalcemia, gastric damage, and emotional behavior in rats" Am. J.Physiol (Regulatory Integr. Comp. Physiol). in press.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Aou, S.: "The effect of B-HT 920, a dopamine D2 agonist, on bar-press feeding in the monkey" Physiol. Behav.in press.

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1995-03-27  

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