1992 Fiscal Year Final Research Report Summary
腫瘍性遺伝疾患の遺伝子背景についての分子病理学的研究
| Project/Area Number |
03454167
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Human pathology
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| Research Institution | KYOTO UNIVERSITY |
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Principal Investigator |
SUGIYAMA Taketoshi Kyoto University Faculty of Medicine Professor, 医学部, 教授 (20030851)
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| Co-Investigator(Kenkyū-buntansha) |
加納 良男 岡山大学, 医学部, 助手 (70116200)
嶋田 俊秀 京都大学, 医学部, 助手 (00235623)
濱崎 周次 京都大学, 医学部, 助手 (50208576)
KANO Y. Okayama University Faculty of Medicine Research Associate
HAMAZAKI S. Kyoto University Faculty of Medicine Research Associate
SHIMADA T. Kyoto University Faculty of Medicine Research Associate
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| Project Period (FY) |
1991 – 1992
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| Keywords | tumor suppressor / gene mutation / loss of heterozygosity / pathological grading / point mutation / oncogene |
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| Research Abstract |
The effects of gene mutations in human cancers were investigated by the molecular pathological analyses. The followings are the important findings from these studies. 1) Ras gene mutation did not correlate with the development of stomach cancer. 2) In urothelial cancers, chromosomal losses on 3p, 11p, 9q and 17p were found to be significant, implicating the evidence of inactivation of related tumor suppressor genes. 3) In hereditary retinoblastoma, short repeat sequences were involved in the break point of deletions. On the other hand, different mutational mechanism could be involved in the development of sporadic bladder cancer. 4) The effects of formalin fixation on DNA samples were also found to be significant under certain conditions.
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