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1993 Fiscal Year Final Research Report Summary

Auqmetation of antitumor immunity by a mixture of OK-432 and fibrinogen

Research Project

Project/Area Number 03454321
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Digestive surgery
Research InstitutionOsaka University

Principal Investigator

MORI Takesada  Osaka Univercity Professor, 医学部, 教授 (60028496)

Co-Investigator(Kenkyū-buntansha) OUE Masayuki  Osaka Univercity Hospital M.D., 医学部・付属病院, 医員
TAKEDA Tsutomu  Osaka Univercity Assistant Professor, 医学部, 助手 (80236471)
TOMITA Naohiro  Osaka Univercity Assistant Professor, 医学部, 助手 (00252643)
MONDEN Takushi  Osaka Univercity Assistant Professor, 医学部, 助手 (20174477)
SHIMANO Takashi  Osaka Univercity Assistant Professor, 医学部, 講師 (80144476)
Project Period (FY) 1991 – 1993
KeywordsOK-432 / fibrinogen / local immuno-therapy / colorectal cancer / giant cells / fibrin mesh / hepato cellularcarunoma / immuroembolization
Research Abstract

OK-432 (5 KE), an antineoplastic agent prepared form an attenuated strain of Streptococcus pyogenes, was dissolved in 1 ml of aprotinin (1,000 KIE) and mixed with 80 mg of fibrinogen containing factor-XIII.A single intratumoral injection of the mixture was administered preoperatively under endoscopy in more than 100 patients with colorectal carcinoma. Postoperative histopathological examinations revealed the formation of fibrin mesh at the site of injection and marked infiltration of inflammatory cells into the tumor stroma on the day following injecton ; the formation of granulomas containing many giant cells after 4 to 7 days ; and extensive destruction of tumor tissue after 14 days. We analyzed the results of a new therapy for hepatocellular carcinoma (HCC) : transarterial immuno-embolization (TIE) with OK-432 and fibrinogen. Of 19 patients with advanced HCC in which other treatments were ineffective, 14 (74%) were surviving at 2 to 16 months after TIE.Serum levels of the tumor markers decreased in all patients and a marked reduction of tumor size was observed in 6 patients after TIE.High fever was observed in all patients. However, deterioration of liver function seemed to be negligible. Histological examination of resected specimens following TIE showed massive infiltration of mononuclear cells around tumor cell nests of the main tumor and intrahepatic metastases.

  • Research Products

    (9 results)

All Other

All Publications (9 results)

  • [Publications] BABA,M.: "Preparation of a human monoclonal antibody derived from cervical lymphnodes of a patient with anaplastic carcinoma of the thyroid." Humantibod hybridomas. 4. 181-185 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] SAKITA,I.: "Augmentation of antitumor immunity in regional lymph node by local immunotherapy." Biotherapy. 6. 103-112 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] YAGYU,T.: "A cancer-reactive human monoclonal antibody derived from a colonic cancer patient treated with local immunotherapy." Jpn J Cancer Res.84. 75-82 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 松浦成昭: "癌と免疫における細胞接着." BIOTHERAPY. 7. 1552-1559 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 武田 力: "乳癌に対するOK-432/fibrinogen局注療法の試み." BIOTHERAPY. 7. 768-770 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 島野高志: "Pancreatic Oncofetal Antigen(POA)." 内科. 71(6). 1449 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 島野高志: "図説臨床[癌]シリーズ癌と免疫,癌の免疫療法(6)溶連菌製剤OK-432" メジカルレビュー社(東京), 150 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 門田卓士: "マイクロウエーブ照射による生物試料の固定・染色法の基本とその応用-in situ hybridization." 学際企画社(東京), 217 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] BABA,M.: "Preparation of a human monoclonal antibady derived from cervical lymphnodes of a patient with anaplastic carcinoma of the thyroid." Humantibod hybridomas. 4. 181-185 (1993)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1995-03-27  

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