1993 Fiscal Year Final Research Report Summary
Peripheral circulatory dynamics under artificial circulation
| Project/Area Number |
03454340
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Thoracic surgery
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| Research Institution | National Cardiovascular Center, Research Institute |
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Principal Investigator |
TAENAKA Yoshiyuki National Cardiovascular Center, Research Institute, Department of Artificial Organs, Laboratory Head, 人工臓器部, 室長 (00142183)
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| Co-Investigator(Kenkyū-buntansha) |
TATSUMI Eisuke National Cardiovascular Center, Research Institute, Department of Artificial Org, 人工臓器部, 研究員 (00216996)
MASUZAWA Toru National Cardiovascular Center, Research Institute, Department of Artificial Org, 人工臓器部, 研究員 (40199691)
NAKATANI Takeshi National Cardiovascular Center, Research Institute, Department of Biomedical Eng, 生体工学部, 室長 (60155752)
TAKANO Hisateru National Cardiovascular Center, Research Institute, Department of Artificial Org, 人工臓器部, 部長 (60028595)
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| Project Period (FY) |
1991 – 1993
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| Keywords | nonpulsatile systemic circulation / nonpulsatile pulmonary circulation / peripheral circulation / thermography / tissue blood flow / colored-microsphere / vasomotion / artificial circulation |
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| Research Abstract |
The purpose of this study is to clarify the influences of artificial circulation on peripheral circulatory dynamics in animal experiments. The artificial circulation includes ventricular assist device, total artificial heart, nonpulsatile pump, veno-arterial or veno-venous bypass and other circulatory support systems. Peripheral circulation was evaluated by changes in hemodynamic parameters, blood chemistry such as catecholamine, tissue blood flow measured by the colored-microsphere method and laser-doppler tissue blood flowmeter and thermography of the skin. Nonpulsatile systemic circulation did not affect peripheral circulatory dynamics and vasomotion of the peripheral vessels was well maintained. Depulsation of the pulmonary circulation was not significantly influenced, either. The distribution of the blood didn't change between ventral and dorsal portion of the lung and lung water content did not alter at all. From the aspect of circulatory control, correlation between cardiac output and peripheral vascular resistance revealed to be negative and peripheral resistance is an important factor to control the circulation even in an animal with an artificial circulation.
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