1993 Fiscal Year Final Research Report Summary
A Study on the pathogenesis and mechanism of occurence of geriatric fractures.
| Project/Area Number |
03454364
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Tottori University |
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Principal Investigator |
YAMAMOTO Kichizo Faculty of Med., Tottori University Prof., 医学部, 教授 (00032326)
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| Co-Investigator(Kenkyū-buntansha) |
HAGINO Hiroshi Faculty of Med., Tottori University lecturer, 医学部・附属病院, 講師 (80208412)
KISHIMOTO Hideaki Faculty of Med., Tottori University lecturer, 医学部, 講師 (00177817)
TESHIMA Ryota Faculty of Med., Tottori University Associ.Prof., 医学部, 助教授 (50144671)
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| Project Period (FY) |
1991 – 1993
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| Keywords | osteoporosis / femoral neck fracture / Histomorphometry / Non-invasive bone mineral measurement / scanning electron microscopy |
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| Research Abstract |
The result of this project consists of three part.
1) Non-invasive bone mineral measurements
The results of bone mineral measurements the spine by DXA was published in the title of "measurements of bone mineral density of lumbar vertebrae in the lateral projection by dual-energy X-ray absorptiometry-comparison with anteroposterior spinal and radial bone mineral measurements-" in J.Jpn. Orthop.Assoc., vol.67 : 49-57,1993. And the results of bone mineral measurements of os calcis was published in the J.Jpn.Orthop.Associ.vol.68 : 1044-1055,1994. under the title of "Bone mineral measurement of the calcaneus by single X-ray absoptiometry" The fracture threshold, defined as the 90% for calcaneus BMC in a women with a vertebral fracture was 313mg/cm^2 and 70.2% of the peak bone mass in the calcaneus.
2) Scanning electron microscopic study of iliac bone biopsy
The functional state of iliac cancellous bone in the postmenopausal women was investigated by SEM and revealed high resorbing activity in the early stage of postmenopause, which was published in Acta Anat. Nipponica vol.68 : 305-315,1993.
3) Histomorphometric Analysis of femoral neck specimen and iliac bone biopsy
To evaluate the bone mass and quality of the femoral neck spcimen and the histomorphometric analysis was performed, which exhibited an increased resorption cavity and intracortical porosity in the cortex as well as endocortical envelop. The bone volume in the femoral neck also significantly lower. However parameters of the iliac bone were not correlated with those of the femoral neck.
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