1992 Fiscal Year Final Research Report Summary
Development of new functional glycans based on glycotechnology
| Project/Area Number |
03660133
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
製造化学・食品
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| Research Institution | Gifu University |
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Principal Investigator |
KISO Makoto Gifu University, Professor, 農学部, 教授 (90092931)
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| Co-Investigator(Kenkyū-buntansha) |
HASEGAWA Akira Gifu University Professor, 農学部, 教授 (10026429)
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| Project Period (FY) |
1991 – 1992
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| Keywords | Glycotechnology / Sialo-oligosaccharides / L-deoxynojirimycin / Functional glycans / Fucosylated glycans |
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| Research Abstract |
1. Not only a variety of sialo- and fucosylated oligosaccharides but also l-deoxynojirimycin (DNJ)-containing glycans have been systematically synthesized by using the corresponding thioglycoside donors. Among those, the DNJ-containing sialyl-Lewis X and sialyl-Lewis A epitopes recognized by LEC-CAMs (selectins) may become very useful for the biomedical applications, especially as the anti-inflammatory and anti-metastatic agents.
2. Chemo-enzymatic synthesis of sialo-oligosaccharides have also been examined by using PNP-Neu5Ac as a glycosyl donor and lactose as a glycosyl acceptor, to give sialyl-alpha(2-3')-lactose as a major product. The partial protection of hydroxyls in glycosyl acceptors may give more regioselectivity.
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[Publications] Hasegawa, A. & Kiso, M.: "Systematic Synthesis of Gangliosides toward the Elucidation and Biomedical Application of Biological Functions." Carbohydrates, Synthetic Methods and Applications in Medicinal Chemistry, Ogura, H., Hasegawa, A. & Suami, T., eds., KODANSHA/VCH, Tokyo. 243-266 (1992)
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